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8-Anilino-1-naphthalenesulfonic acid

Name: 8-Anilino-1-naphthalenesulfonic acid
Brand: SIAL

≥97% purity (HPLC), powder

Synonym(s):

N-Phenyl peri acid, ANS, ANSA

About This Item

Linear Formula:

C₆H₅NHC₁₀H₆SO₃H

CAS Number:

82-76-8

Molecular Weight:

299.34

NACRES:

NA.47

PubChem Substance ID:

24890494

UNSPSC Code:

12171500

MDL number:

MFCD00003998

Beilstein/REAXYS Number:

1843887

This product is discontinued. Contact Technical Servicefor assistance.

Properties

Product Name

8-Anilino-1-naphthalenesulfonic acid,

assay

≥97% (HPLC)

Quality Level

200

form

powder

composition

, <0.5% (solvent)

color

black, gray to dark green

mp

215-217 °C (dec.) (lit.)

solubility

DMF: 50 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12

InChI

1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)

InChI key

FWEOQOXTVHGIFQ-UHFFFAOYSA-N

Description

Application

8-Anilino-1-naphthalenesulfonic acid (ANS) has been used to study the thermal aggregation of BSA (bovine serum albumin).

Biochem/physiol Actions

8-Anilino-1-naphthalenesulfonic acid (ANS) is an important dye which is used to study the intermediate states in the folding/unfolding pathways of proteins. It is also useful to check the conformational changes involved with the aggregation of proteins. ANS is nonfluorescent in the aqueous solution, however, it fluoresces strongly upon binding to BSA (bovine serum albumin) and denatured proteins. It is used for the detection of albumin in the serum. ANS mainly interacts with the solvent exposed nonpolar (hydrophobic) sites.

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1 of 1

This Item	D4645	10417	H1252
Sigma-Aldrich A1028 8-Anilino-1-naphthalenesulfonic acid	Sigma-Aldrich D4645 Sodium 3,5-dichloro-2-hydroxybenzenesulfonate	Sigma-Aldrich 10417 8-Anilino-1-naphthalenesulfonic acid ammonium salt	Sigma-Aldrich H1252 Homovanillic acid
color black, gray to dark green	color white to off-white	color faint gray to gray	color white to off-white
solubility DMF: 50 mg/mL	solubility H₂O: 50 mg/mL	solubility H₂O: 0.1 g/5mL, clear to very slightly hazy (hot), NaOH: 1 N, H₂O: soluble, acetone: soluble, methanol: soluble	solubility ethanol: 50 mg/mL, colorless to light yellow
application(s) diagnostic assay manufacturing hematology histology	application(s) diagnostic assay manufacturing hematology histology	application(s) -	application(s) diagnostic assay manufacturing hematology histology
form powder	form powder	form solid	form powder
composition , <0.5% (solvent)	composition -	composition -	composition -
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Thermal aggregation of glycated bovine serum albumin.

Rondeau P, et al.

Biochimica et Biophysica Acta, 1804, 789-789 (2010)

Uversky VN and Permiakov EA

Methods in Protein Structure and Stability Analysis (2007)

Thermal aggregation of bovine serum albumin at different pH: comparison with human serum albumin.

Vetri V, et al.

European Biophysics Journal, 36, 717-717 (2007)

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Global Trade Item Number

SKU	GTIN
A1028-5G	04061833334683
A1028-100G	04061833334669
A1028-25G	04061833334676

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