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A1320000

Aspartame

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Asp-Phe methyl ester, N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame
Linear Formula:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
CAS Number:
Molecular Weight:
294.30
Beilstein/REAXYS Number:
2223850
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

agency

EP Reference Standard

API family

aspartame

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O

InChI

1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1

InChI key

IAOZJIPTCAWIRG-QWRGUYRKSA-N

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1 of 4

This Item
104370647135PHR1381
Aspartame European Pharmacopoeia (EP) Reference Standard

A1320000

Aspartame

Aspartame United States Pharmacopeia (USP) Reference Standard

1043706

Aspartame

Aspartame analytical standard

47135

Aspartame

Aspartame Pharmaceutical Secondary Standard; Certified Reference Material

PHR1381

Aspartame

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

agency

EP Reference Standard

agency

-

agency

-

agency

traceable to Ph. Eur. A1320000, traceable to USP 1043706

API family

aspartame

API family

aspartame

API family

-

API family

aspartame

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aspartame EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Maria Maersk et al.
The American journal of clinical nutrition, 95(2), 283-289 (2011-12-30)
The consumption of sucrose-sweetened soft drinks (SSSDs) has been associated with obesity, the metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies. Too few long-term intervention studies in humans have examined the effects of soft drinks. We compared
Jean-Daniel Berset et al.
Chemosphere, 88(5), 563-569 (2012-04-17)
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of
Eva S Schernhammer et al.
The American journal of clinical nutrition, 96(6), 1419-1428 (2012-10-26)
Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. We repeatedly assessed diet in the Nurses' Health Study (NHS) and
B A Magnuson et al.
Critical reviews in toxicology, 37(8), 629-727 (2007-09-11)
Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. The purpose of this investigation was to review the scientific literature on the absorption and metabolism, the
Harriett H Butchko et al.
Regulatory toxicology and pharmacology : RTP, 35(2 Pt 2), S1-93 (2002-08-16)
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than

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