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A3648

(3-Aminopropyl)triethoxysilane

≥98%

Synonym(s):

APTS, 3-Triethoxysilylpropylamine, APTES

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Size/SKUAvailabilityPrice
100 mL

Available to ship TODAYfromMILWAUKEE

$102.00
500 mL

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$360.00

About This Item

Linear Formula:
H2N(CH2)3Si(OC2H5)3
CAS Number:
Molecular Weight:
221.37
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
213-048-4
Beilstein/REAXYS Number:
1754988
MDL number:

$102.00


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Quality Segment

assay

≥98%

form

liquid

pH

11 (20 °C, 20 g/L)

bp

217 °C/760 mmHg (lit.)

mp

220-222 °C

density

0.946 g/mL at 25 °C (lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

CCO[Si](CCCN)(OCC)OCC

InChI

1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3

InChI key

WYTZZXDRDKSJID-UHFFFAOYSA-N

Application

  • (3-Aminopropyl)triethoxysilane has been used for the preparation of cadherin surfaces on glass slides.[1]
  • It has been used for the preparation of RGD (Arg-Gly-Asp)-treated silicone membranes.
  • It has been used for the preparation of the avidin–biotin coverslips.

Biochem/physiol Actions

(3-Aminopropyl)triethoxysilane forms aminopropyl derivative of glass, an adsorbent for affinity chromatography. It is used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures.[2]

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This Item
44014074144250059
assay

≥98%

assay

99%

assay

≥98.0%

assay

≥97.0% (GC)

form

liquid

form

liquid

form

liquid

form

-

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

-

mp

220-222 °C

mp

-

mp

-

mp

-

density

0.946 g/mL at 25 °C (lit.)

density

0.946 g/mL at 25 °C (lit.)

density

0.929 g/mL at 25 °C, 0.946 g/mL at 25 °C (lit.)

density

1.004 g/mL at 20 °C (lit.)

bp

217 °C/760 mmHg (lit.)

bp

217 °C/760 mmHg (lit.)

bp

217 °C/760 mmHg (lit.)

bp

-


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pictograms

CorrosionExclamation mark

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

199.4 °F - closed cup

flash_point_c

93 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter



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Questions

1–6 of 6 Questions  
  1. What is the concentration of the (3-Aminopropyl)triethoxysilane, commonly known as APTES?

    1 answer
    1. The (3-Aminopropyl)triethoxysilane, which is a neat liquid, is 4.3 M. This is based on a density of 0.946 g/mL and a molecular weight of 221.37.

      Helpful?

  2. Can the coating made from product A3648, (3-Aminopropyl)triethoxysilane, be removed?

    1 answer
    1. For Product A3648, (3-Aminopropyl)triethoxysilane, the siliconized coating can be removed by an overnight treatment with 10-20% (w/v) aqueous or alcoholic potassium hydroxide or sodium hydroxide solutions. It may also be possible to remove the coating by physical abrasion, i.e., scrubbing or vigorously brushing the glass surface. Autoclaving will not destroy the coating.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. How does Product A3648, (3-Aminopropyl)triethoxysilane, compare to poly-L-lysine for binding tissue to glass surfaces?

    1 answer
    1. This product has been cited as being a better tissue adhesive than poly-L-lysine. Maddox PH, Jenkins D., 3-Aminopropyltriethoxysilane (APES): a new advance in section adhesion. J Clin Pathol., 40(10):1256-7 (1987).

      Helpful?

  5. Can I buy glass slides already treated with Product A3648, (3-Aminopropyl)triethoxysilane?

    1 answer
    1. Yes. Silane Prep slides, Product No. S4651, are produced using A3648. These slides have an expiration period of 24 months.

      Helpful?

  6. Can Product A3648, (3-Aminopropyl)triethoxysilane, be used to coat controlled pore glass?

    1 answer
    1. To coat controlled-pore glass beads for affinity chromatography, the following method is recommended:1. Treat 1 g of clean beads with 20 mL of a 10% aqueous A3648 (pH 3 to 4) at 75 °C for 2 hours.2. Filter the beads to remove the solution and dry overnight in a 115 °C oven. See: J. Dairy Sci., 73, 2720-2730 (1990).

      Helpful?

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