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A3723

Sigma-Aldrich

ADVASEP-7

solid

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Linear Formula:
C42H70-nO35(C4H6SO3Na)n, avg. n = 6.5
NACRES:
NA.47

form

solid

Quality Level

mol wt

~2163

color

white

solubility

H2O: soluble

application(s)

hematology
histology

storage temp.

−20°C

Application

ADVASEP-7 has been used in washing solution to remove excess dyes, FM4-64FX and FM1-43, in stained cells.

Biochem/physiol Actions

ADVASEP-7 is a β-cyclodextran derivative. It works as a dye scavenger and removes the background dye.
Reduces background staining of plasma membrane with SynaptoGreen.

Other Notes

Sulfonated β-cyclodextrin. Component of NTSI, NTSII, and NTSV, also sold individually.

Legal Information

Advasep is a trademark of Cydex Pharmaceuticals, Inc.
SynaptoGreen is a trademark of Biotium, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A R Kay et al.
Neuron, 24(4), 809-817 (2000-01-07)
The fluorescent probe FM1-43 has been used extensively for imaging vesicle recycling; however, high nonspecific adsorption resulting in elevated background levels has precluded its use in certain tissues, notably brain slices. We have found that a sulfobutylated derivative of beta-cyclodextrin
Imaging synaptic vesicle exocytosis and endocytosis with FM dyes.
Gaffield MA and Betz WJ
Nature Protocols, 1, 2916-2916 (2006)
The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype.
Hosseinibarkooie S, et al.
American Journal of Human Genetics, 99, 647-647 (2016)
Samuel Lundt et al.
Scientific reports, 10(1), 99-99 (2020-01-11)
Nicotinamide adenine dinucleotide (NAD+) plays a critical role in energy metabolism and bioenergetic homeostasis. Most NAD+ in mammalian cells is synthesized via the NAD+ salvage pathway, where nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme, converting nicotinamide into nicotinamide mononucleotide (NMN).
?-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Brown LE, et al.
The Journal of Biological Chemistry, 291, 13926-13926 (2016)

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