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A8251

Sigma-Aldrich

Acriflavine hydrochloride

fluorescent dye

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Synonym(s):
3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine
CAS Number:
Beilstein:
6265525
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

form

powder

mp

260 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

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1 of 4

This Item
A8126318337A8097
Acriflavine fluorescent label

Sigma-Aldrich

A8126

Acriflavine

mp

260 °C (dec.) (lit.)

mp

179-181 °C

mp

284-287 °C (lit.)

mp

-

solubility

H2O: 1 mg/mL

solubility

H2O: 0.33 g/mL (lit.)(lit.)

solubility

H2O: 0.1%, clear, orange to red

solubility

-

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

200

Application

In living mice, acriflavine hydrochloride has been used in the confocal laser endomicroscopy to check the crypt structure in mucosa. It has also been used in Neurospora strain selection by checking the acriflavine resistance.

Biochem/physiol Actions

Acriflavine hydrochloride is a fluorescent dye. It is used as a topical contrast agent. It mainly stains nuclei and is applied to tissues before microscopy.

Other Notes

A mixture of 3,6-diamino-10-methylacridinium (acriflavin) and 3,6-diaminoacridine (proflavin)

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice.
Waldner MJ, et al.
Nature Protocols, 6, 1471-1481 (2011)
Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract.
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