A8251

Sigma-Aldrich

Acriflavine hydrochloride

Synonym(s):
3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine
CAS Number:
Beilstein/REAXYS Number:
6265525
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

application(s)

hematology: suitable
histology: suitable

mp

260 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

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Application

In living mice, acriflavine hydrochloride has been used in the confocal laser endomicroscopy to check the crypt structure in mucosa. It has also been used in Neurospora strain selection by checking the acriflavine resistance.

Packaging

10, 25, 100 g in glass bottle

Biochem/physiol Actions

Acriflavine hydrochloride is a fluorescent dye. It is used as a topical contrast agent. It mainly stains nuclei and is applied to tissues before microscopy.

Other Notes

A mixture of 3,6-diamino-10-methylacridinium (acriflavin) and 3,6-diaminoacridine (proflavin)

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract.
Goetz M and Kiesslich R
Anticancer Research, 28, 353-360 (2008)
Jian Yang et al.
Journal of the American Heart Association, 7(5) (2018-02-27)
Limb remote ischemic preconditioning (RIPC) protects against brain injury induced by stroke, but the underlying protective mechanisms remain unknown. As hypoxia inducible factor 1α (HIF-1α) is neuroprotective in stroke and mediates neuroinflammation, we tested the hypothesis that HIF-1α is a...
period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock.
Emerson JM, et al.
Proceedings of the National Academy of Sciences of the USA, 112, 15707-15712 (2015)
Xiangnan Du et al.
Frontiers in aging neuroscience, 12, 54-54 (2020-03-27)
Limb remote ischemic preconditioning (RIPC) has been proven to alleviate stroke injury in young rats, but its protective effect and its mechanism in aged rats are still unclear. Hypoxia-inducible factor (HIF) is one of the important markers of stroke, and...
Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice.
Waldner MJ, et al.
Nature Protocols, 6, 1471-1481 (2011)

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