ARK2164

SAFC

Fumaric acid

PharmaGrade, USP/NF, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.

Linear Formula:
HOOCCH=CHCOOH
CAS Number:
Molecular Weight:
116.07
Beilstein/REAXYS Number:
605763
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

biological source

synthetic

Agency/Method

USP/NF

vapor pressure

1.7 mmHg ( 165 °C)

product line

PharmaGrade

assay

≥99.5%

form

powder

autoignition temp.

1364 °F

expl. lim.

40 %

mp

298-300 °C (subl.) (lit.)

suitability

suitable for manufacturing use

SMILES string

OC(=O)\C=C\C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

InChI key

VZCYOOQTPOCHFL-OWOJBTEDSA-N

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

WGK Germany

WGK 1

Flash Point(F)

521.6 - 525.2 °F - open cup

Flash Point(C)

272 - 274 °C - open cup

R Gold et al.
Clinical immunology (Orlando, Fla.), 142(1), 44-48 (2011-03-19)
Fumaric acid was originally therapeutically used in psoriasis. Several lines of evidence have demonstrated immunomodulatory but also neuroprotective effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4+ and CD8+ T-lymphocytes due to the ability of FAE...
Qing Xu et al.
Biotechnology advances, 30(6), 1685-1696 (2012-09-04)
The growing concern about the safety of food and dairy additives and the increasing costs of petroleum-based chemicals have rekindled the interest in the fermentation processes for fumaric acid production. The key problems of the industrial production of microbial fumaric...
Mingda Bi et al.
Journal of pharmaceutical sciences, 103(7), 2062-2071 (2014-05-21)
The purpose of this study is to investigate if Johanson's rolling theory can correctly predict the maximum roll surface pressure during the roll compaction. Three model pharmaceutical formulations were roller compacted using the Gerteis Mini Pactor at multiple combinations of...
Fumaric acid esters, their place in the treatment of psoriasis.
A D Ormerod et al.
The British journal of dermatology, 150(4), 630-632 (2004-04-22)
C Nieboer et al.
Journal of the American Academy of Dermatology, 20(4), 601-608 (1989-04-01)
For the past two decades fumaric acid (FA) therapy has become an increasingly popular treatment in Western Europe for psoriasis. FA therapy originally was developed by Schweckendiek and subsequently standardized by Schäfer. Schäfer's fumaric acid compound therapy (FACT) consists of...

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