B0470000

Benperidol

Name: Benperidol
Brand: SIAL
Price: 254 USD

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-{1-[4-(4-Fluorophenyl)-4-oxobutyl]-piperidin-4-yl}-1,3-dihydro-benzimidazol-2-one

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100 MG

$254.00

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₄FN₃O₂

CAS Number:

2062-84-2

Molecular Weight:

381.44

MDL number:

MFCD00866672

UNSPSC Code:

41116107

NACRES:

NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

benperidol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)[n]3c4c([nH][c]3=O)cccc4

InChI

1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)

InChI key

FEBOTPHFXYHVPL-UHFFFAOYSA-N

Related Categories

Pharmacopeia & Metrological Institute Standards

Analytical Reference Materials for Pharma QC

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Show Differences

1 of 4

This Item	B1152050	B1152000	H0100100
B0470000 Benperidol	B1152050 Bromperidol decanoate	B1152000 Bromperidol	H0100100 Haloperidol decanoate
manufacturer/tradename EDQM	manufacturer/tradename EDQM	manufacturer/tradename EDQM	manufacturer/tradename EDQM
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family benperidol	API family bromperidol	API family bromperidol	API family haloperidol
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benperidol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

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Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol.

Carlos Schönfeldt-Lecuona et al.

Journal of clinical psychopharmacology, 24(1), 97-98 (2004-01-08)

Gender differences in D2 dopamine receptor binding in drug-naive patients with schizophrenia: an [123I]iodobenzamide single photon emission computed tomography study.

J Schröder et al.

Psychiatry research, 75(2), 115-123 (1997-11-14)

Recent studies have described a left lateralized striatal asymmetry of D2 dopamine receptors in male patients with schizophrenia. To replicate this finding and to explore its potential functional consequences, we investigated the D2 dopamine receptor system in 23 drug-naive patients

Voltammetric determination of droperidol and benperidol.

I Biryol et al.

Journal of pharmaceutical and biomedical analysis, 15(11), 1695-1701 (1997-07-01)

In this study two butyrophenones, droperidol and benperidol were voltammetrically investigated using platinum and specially activated glass carbon electrodes. The behaviours of the substance were investigated in various electrolyte solutions having different pH values and by different scan rates. As

Specific, reversible binding of [18F]benperidol to baboon D2 receptors: PET evaluation of an improved 18F-labeled ligand.

S M Moerlein et al.

Nuclear medicine and biology, 22(6), 809-815 (1995-08-01)

[18F]Benperidol ([18F]BP), a positron-emitting analogue of the dopaminergic D2 antagonist benperidol, was evaluated as a radiopharmaceutical for use with positron emission tomography (PET). PET imaging of baboons after i.v. injection of [18F]BP indicated that the radiofluorinated ligand rapidly localized in

[D2-dopamine receptor upregulation and treatment response under neuroleptic therapy].

J Schröder et al.

Fortschritte der Neurologie-Psychiatrie, 68 Suppl 1, S42-S45 (2000-07-25)

Animal and post mortem studies indicate that neuroleptic therapy may induce D2-dopamine receptor upregulation in the basal ganglia. To address this phenomenon in a clinical study, we investigated the D2-dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state

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Global Trade Item Number

SKU	GTIN
B0470000	04061833799314

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