B5887

Sodium butyrate

≥98.5% (GC)

• Synonym(s): Butyric acid sodium salt
• Linear Formula: CH₃CH₂CH₂COONa
• CAS Number: 156-54-7
• Molecular Weight: 110.09
• Beilstein: 3629439
• EC Number: 205-857-6
• MDL number: MFCD00002816
• PubChem Substance ID: 24891873
• NACRES: NA.25

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥98.5% (GC)
• form: powder
• mp: 250-253 °C (lit.)
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless
• storage temp.: room temp
• SMILES string: [Na+].CCCC([O-])=O
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
• InChI key: MFBOGIVSZKQAPD-UHFFFAOYSA-M
• Gene Information: mouse ... ENSMUSG00000061062(15181)

Description

Application

Sodium butyrate has been used:

• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca²⁺ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Caution

Hygroscopic

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315 - H319
• Precautionary Statements: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves