BCR096

Dibenzo[a,l]pyrene

Name: Dibenzo[<I>a</I>,<I>l</I>]pyrene
Brand: SIAL
Price: 1290 USD

BCR^®, certified reference material

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100 MG

$1,290.00

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₄

CAS Number:

191-30-0

Molecular Weight:

302.37

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329774220

MDL number:

MFCD00467035

Beilstein/REAXYS Number:

2054068

Key Documents

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Product Name

Dibenzo[a,l]pyrene, BCR^®, certified reference material

InChI

1S/C24H14/c1-2-8-18-16(6-1)14-17-13-12-15-7-5-11-20-19-9-3-4-10-21(19)24(18)23(17)22(15)20/h1-14H

SMILES string

c1ccc2c(c1)cc3ccc4cccc5c6ccccc6c2c3c45

InChI key

JNTHRSHGARDABO-UHFFFAOYSA-N

grade

certified reference material

agency

BCR^®

manufacturer/tradename

JRC

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

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Show Differences

1 of 4

This Item	BCR159	BCR133	BCR337
BCR096 Dibenzo[a,l]pyrene	BCR159 Dibenzo[a,h]pyrene	BCR133 Dibenzo[a,e]pyrene	BCR337 Dibenzo[b,d]furan
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
format neat	format neat	format neat	format neat
grade certified reference material	grade certified reference material	grade certified reference material	grade certified reference material
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
manufacturer/tradename JRC	manufacturer/tradename JRC	manufacturer/tradename JRC	manufacturer/tradename JRC
agency BCR^®	agency BCR^®	agency BCR^®	agency BCR^®

Analysis Note

For more information please see:
BCR096

Legal Information

BCR is a registered trademark of European Commission

pictograms

GHS08,GHS05

signalword

Danger

hcodes

H318,H341,H350

pcodes

P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 1B - Eye Dam. 1 - Muta. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.

Yijin Tang et al.

Biochemistry, 51(48), 9751-9762 (2012-11-06)

The most potent tumorigen identified among the polycyclic aromatic hydrocarbons (PAH) is the nonplanar fjord region dibenzo[a,l]pyrene (DB[a,l]P). It is metabolically activated in vivo through the widely studied diol epoxide (DE) pathway to form covalent adducts with DNA bases, predominantly

Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS.

Shang-Min Zhang et al.

Chemical research in toxicology, 24(8), 1297-1303 (2011-07-09)

Tobacco smoking is one of the leading causes for oral cancer. Dibenzo[a,l]pyrene (DB[a,l]P), an environmental pollutant and a tobacco smoke constituent, is the most carcinogenic polycyclic aromatic hydrocarbon (PAH) tested to date in several animal models (target organs: skin, lung

A bulky DNA lesion derived from a highly potent polycyclic aromatic tumorigen stabilizes nucleosome core particle structure.

Yuqin Cai et al.

Biochemistry, 49(46), 9943-9945 (2010-10-23)

The impact of a bulky DNA lesion on the structure and dynamics of a nucleosome core particle (NCP) containing a lesion derived from the unusually potent tumorigen dibenzo[a,l]pyrene that resists nucleotide excision repair (NER) in free DNA was investigated using

Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.

Lyndsey E Shorey et al.

Cancer letters, 317(1), 49-55 (2011-11-17)

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established

Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.

Tammie J McQuistan et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(2), 341-352 (2011-11-15)

Recent pilot studies found natural chlorophyll (Chl) to inhibit carcinogen uptake and tumorigenesis in rodent and fish models, and to alter uptake and biodistribution of trace (14)C-aflatoxin B1 in human volunteers. The present study extends these promising findings, using a

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