BP576

Hydrocortisone

British Pharmacopoeia (BP) Assay Standard

• Synonym(s): 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Empirical Formula (Hill Notation): C₂₁H₃₀O₅
• CAS Number: 50-23-7
• Molecular Weight: 362.46
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 1354819
• MDL number: MFCD00011654

Properties

• grade: pharmaceutical primary standard
• API family: hydrocortisone
• form: solid
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• mp: 211-214 °C (lit.)
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Tretinoin, Hydrocortisone and Hydroquinone Cream

Miconazole and Hydrocortisone Acetate Cream

Hydrocortisone Sodium Succinate Injection

Prednisolone Tablets

Miconazole and Hydrocortisone Cream

Miconazole and Hydrocortisone Ointment

Hydrocortisone and Neomycin Cream

Hydrocortisone and Clioquinol Ointment

Hydrocortisone Sodium Phosphate Oral Solution

Prednisolone Gastro-resistant Tablets

Hydrocortisone Sodium Phosphate

Hydrocortisone Sodium Phosphate Injection

Hydrocortisone and Clioquinol Cream

Methylprednisolone Tablets

Hydrocortisone Acetate Oral Suspension

Hydrocortisone Cream

Hydrocortisone Oromucosal Tablets

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Primary glucocorticoid secreted by the adrenal cortex.

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H360Df,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Target Organs: Adrenal gland,Bone marrow
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable