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MilliporeSigma

C1528

Cocaine hydrochloride solution

1.0 mg/mL in methanol, analytical standard, for drug analysis

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1 ML

$78.40

$78.40


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About This Item

Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
Molecular Weight:
339.81
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:

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InChI key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

SMILES string

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

drug control

Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; (Spain); Decreto Lei 15/93: Tabela IB (Portugal), kontrollierte Droge in Deutschland

Quality Level

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

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1 of 4

This Item
B7536M8536C-008
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

format

single component solution

format

single component solution

format

single component solution

format

single component solution

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

grade

analytical standard, for drug analysis

grade

analytical standard, for drug analysis

grade

drug standard

grade

certified reference material

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

concentration

1.0 mg/mL in methanol

concentration

-

concentration

1.0 mg/mL in methanol

concentration

1.0 mg/mL in acetonitrile

General description

Cocaine is mostly commonly available as cocaine hydrochloride which is a white to off-white powder. It is taken by intranasal route. In some surgeries it is used as topical anaesthetic drug.

Application

Cocaine hydrochloride solution was used as a calibration standard to determine cocaine in human hair samples using gas chromatography/mass spectrometry (GC/MS).[1] It may be used as a standard in the quantitative analysis of cocaine and its adulterants like lidocaine and livamisole using dragendorff reagent combined with paper spray ionization mass spectrometry.[2]

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Certificates of Analysis (COA)

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Quantification of cocaine and its adulterants (lidocaine and levamisole) using the Dragendorff reagent allied to paper spray ionization mass spectrometry
Santos.H, et al.
Analytical Methods : Advancing Methods and Applications (2017)
L Skender et al.
Forensic science international, 125(2-3), 120-126 (2002-03-23)
Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in
Billy T Chen et al.
Nature, 496(7445), 359-362 (2013-04-05)
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. Human studies have suggested that deficits in prefrontal cortical function and
Emmanuelle Jordi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9511-9516 (2013-05-22)
Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in striatal neurons. These changes are thought to participate in physiological memory mechanisms and to be critical for long-term behavioral
John W Muschamp et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), E1648-E1655 (2014-04-08)
Hypocretin (orexin) and dynorphin are neuropeptides with opposing actions on motivated behavior. Orexin is implicated in states of arousal and reward, whereas dynorphin is implicated in depressive-like states. We show that, despite their opposing actions, these peptides are packaged in

Protocols

Analytical standards for drug analysis including heroin, cocaine, amphetamine, and methylenedioxymethamphetamine.

Questions

  1. Does this require submission of a DEA schedule II-V license to purchase?

    1 answer
    1. This product is a DEA Class Exempt preparation of a Class II substance and does not require any type of license submission for purchase. An example of a cocaine hydrochloride product that will require licensing is Product C5776

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