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C2180000

Cinnarizine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-trans-Cinnamyl-4-diphenylmethylpiperazine

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About This Item

Empirical Formula (Hill Notation):
C26H28N2
CAS Number:
298-57-7
Molecular Weight:
368.51
MDL number:
MFCD00056037
UNSPSC Code:
41116107
PubChem Substance ID:
329774975
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

cinnarizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C1CN(CCN1C\C=C\c2ccccc2)C(c3ccccc3)c4ccccc4

InChI

1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+

InChI key

DERZBLKQOCDDDZ-JLHYYAGUSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), HRH1(3269)

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1 of 4

This Item
C0980650Y0001197C0980651
Cinnarizine European Pharmacopoeia (EP) Reference Standard

C2180000

Cinnarizine

Cetirizine dihydrochloride European Pharmacopoeia (EP) Reference Standard

C0980650

Cetirizine dihydrochloride

Cetirizine for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001197

Cetirizine for peak identification

Cetirizine impurity A European Pharmacopoeia (EP) Reference Standard

C0980651

Cetirizine impurity A

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

cinnarizine

API family

cetirizine

API family

cetirizine

API family

cetirizine

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

-

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cinnarizine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jed Zaretzki et al.
Bioinformatics (Oxford, England), 29(4), 497-498 (2012-12-18)
Regioselectivity-WebPredictor (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOMs) on drug-like molecules. Predictions may be made for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19
Pieterjan Kayaert et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(3), 650-656 (2012-05-15)
One of the benefits of nanocrystals is their positive effect on the solubility and dissolution rate without alterations to the solid state. Up to now, amorphization of nanocrystals after milling or drying has only rarely been described. The results we
Pieterjan Kayaert et al.
The Journal of pharmacy and pharmacology, 63(11), 1446-1453 (2011-10-13)
In this article the feasibility of fluidized bed bead coating of nanosuspensions of drugs with significantly different physicochemical properties was investigated as a process to transform nanosuspensions into a solid dosage form. The second aim was to see how those
Tri-Hung Nguyen et al.
Journal of controlled release : official journal of the Controlled Release Society, 153(2), 180-186 (2011-04-19)
This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V(2)) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown
Mohamed A Alhnan et al.
International journal of pharmaceutics, 416(1), 55-60 (2011-06-18)
Poorly water soluble basic drugs are very sensitive to pH changes and following dissolution in the acidic stomach environment tend to precipitate upon gastric emptying, which leads to compromised or erratic oral bioavailability. In this work, we show that the
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