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Cyclophosphamide

Name: Cyclophosphamide
Brand: SIAL
Price: 267 USD
Availability: InStock

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Cyclophosphamide monohydrate, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

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Size/SKU	Availability	Price
50 mg	Available to ship TODAYfromMILWAUKEE	$267.00

About This Item

Empirical Formula (Hill Notation):

C₇H₁₅Cl₂N₂O₂P · H₂O

CAS Number:

6055-19-2

Molecular Weight:

279.10

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329775031

MDL number:

MFCD00149395

Beilstein/REAXYS Number:

4678992

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Properties

grade

pharmaceutical primary standard

API family

cyclophosphamide

manufacturer/tradename

EDQM

mp

49-51 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChI key

PWOQRKCAHTVFLB-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cyclophosphamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Compare Similar Items

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1 of 1

This Item	PHR1404	93813	C0768
C3250000 Cyclophosphamide	Supelco PHR1404 Cyclophosphamide	Supelco 93813 Cyclophosphamide monohydrate	Sigma-Aldrich C0768 Cyclophosphamide monohydrate
grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade analytical standard	grade -
manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) forensics and toxicology veterinary	application(s) -
format neat	format neat	format neat	format -
mp 49-51 °C (lit.)	mp 49-51 °C (lit.)	mp 47-52 °C, 49-51 °C (lit.)	mp 49-51 °C (lit.)
API family cyclophosphamide	API family cyclophosphamide	API family -	API family -

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H340,H350,H360FD

pcodes

P202 - P264 - P270 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Questions

1–3 of 3 Questions

Anonymous

11 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  11 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

a year ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  a year ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
3 years ago

¿Para poder resuspender el producto, se podría usar PBS?

1 answer
1. Technical Support
  
  3 years ago
  
  This is a product of the European Pharmacopoeia. Solubility information is not provided by the supplier. However, the research grade product C0768 is the same compound and the solubility information may be applied to the EP standard. The compound is soluble in water at 40mg/mL. Please see the following link for the product information : https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/268/329/c0768pis.pdf
  Please see this link to contact EP directly:
  https://crs.edqm.eu/db/4DCGI/View=C3250000
  
  Helpful?

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