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C5548

Sigma-Aldrich

Clobetasone butyrate

≥98%

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Synonym(s):
21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
Empirical Formula (Hill Notation):
C26H32ClFO5
CAS Number:
Molecular Weight:
478.98
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

Assay

≥98%

form

powder

solubility

chloroform: 50 mg/mL, clear, faintly yellow

ε (extinction coefficient)

13.4 at 243 nm in chloroform

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl

InChI

1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1

InChI key

FBRAWBYQGRLCEK-AVVSTMBFSA-N

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1 of 4

This Item
C2755C3130P6254
Clobetasone butyrate ≥98%

Sigma-Aldrich

C5548

Clobetasone butyrate

Cortisone ≥95%

Sigma-Aldrich

C2755

Cortisone

Cortisone 21-acetate ≥99%

Sigma-Aldrich

C3130

Cortisone 21-acetate

Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

form

powder

form

powder

form

powder

form

powder

solubility

chloroform: 50 mg/mL, clear, faintly yellow

solubility

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow

ε (extinction coefficient)

13.4 at 243 nm in chloroform

ε (extinction coefficient)

-

ε (extinction coefficient)

-

ε (extinction coefficient)

-

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

application(s)

-

application(s)

hematology

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

General description

Clobetasone butyrate is a corticosteroid.

Application

Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate.
Clobetasone butyrate has been used to analyze its bio-concentration factor (BCF) in Cyprinus carpio.

Biochem/physiol Actions

Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in Sjogrens syndrome.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Community Pharmacy - E-Book: Symptoms Diagnosis and Treatment (2011)
Safety and efficacy of 0.1% clobetasone butyrate eyedrops in the treatment of dry eye in Sjogren syndrome
Aragona P, et al.
European Journal of Ophthalmology, 23(3) (2013)
Liquid chromatography--tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis
Sparidans RW, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(23), 2150-2154 (2010)
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)
Nakayama K, et al.
Marine Pollution Bulletin, 85(2), 370-375 (2014)
Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis
Wolkerstorfer A, et al.
Journal of the American Academy of Dermatology, 39(2), 226-231 (1998)

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