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C7129

Sigma-Aldrich

Citric acid monohydrate

reagent grade, ≥98% (GC/titration)

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Synonym(s):
2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein:
4018641
EC Number:
MDL number:
PubChem Substance ID:

grade

reagent grade

Assay

≥98% (GC/titration)

form

powder

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

solubility

H2O: 100 mg/mL, clear, colorless (Turbidity)

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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This Item
C19091.37003PHR2903
Citric acid monohydrate crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.37003

Citric acid monohydrate

Citric acid Monohydrate pharmaceutical secondary standard, certified reference material

Supelco

PHR2903

Citric acid Monohydrate

assay

≥98% (GC/titration)

assay

≥99.0%

assay

-

assay

-

form

powder

form

powder

form

crystalline, solid

form

-

solubility

H2O: 100 mg/mL, clear, colorless (Turbidity)

solubility

H2O: soluble 54 % (w/w) at 10 °C (Citric acid in water), H2O: 59.2 % (w/w) at 20 °C (Citric acid in water), H2O: 84.0 % (w/w) at 100 °C (Citric acid in water)

solubility

880 g/L

solubility

-

Quality Level

300

Quality Level

200

Quality Level

500

Quality Level

300

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

General description

Citric acid monohydrate(CAM) is an organic acid. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061±123)Jmol-1. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Application

Citric acid monohydrate may be used:
  • To prepare citric acid solution employed in the acetone method of 68Ga pre-purification and radiolabeling technique.
  • To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.
  • To improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

345.0 °F - closed cup

Flash Point(C)

173.9 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

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1 of 4

Size dependency of citric acid monohydrate growth kinetics.
Bravi M and Mazzarotta B.
Chemical Engineering Journal, 70(3), 203-207 (1998)
Michael K Schultz et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 76, 46-54 (2012-10-03)
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.
R K Selander et al.
Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)
New perspectives for citric acid production and application.
Soccol CR, et al.
Food Technology and Biotechnology, 44(2), 141-149 (2006)
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem

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