This product may be stored at room temperature. The material has not been tested for sensitivity to light at specific wavelengths. However, therapeutic products under the name Leucovorin are considered UV sensitive. Please see the link below to review a publication that may be of interest:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3940680/
F7878
Folinic acid calcium salt hydrate
analytical standard
Synonym(s):
5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Available to ship TODAYfromMILWAUKEE | $117.00 | |
| 500 mg | Available to ship TODAYfromMILWAUKEE | $376.00 | |
| 1 g | Available to ship TODAYfromMILWAUKEE | $708.00 |
About This Item
Empirical Formula (Hill Notation):
C20H21CaN7O7 · xH2O
CAS Number:
Molecular Weight:
511.50 (anhydrous basis)
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Beilstein/REAXYS Number:
5723924
biological source
synthetic (organic)
Quality Level
grade
analytical standard
assay
≥90.0%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
yellow to orange
mp
240-250 °C
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
InChI
1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
InChI key
KVUAALJSMIVURS-ZEDZUCNESA-L
General description
Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.
Application
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.
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This Item | |||
|---|---|---|---|
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| application(s) forensics and toxicology | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) |
| format neat | format neat | format - | format neat |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| grade analytical standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade certified reference material, pharmaceutical secondary standard |
| assay ≥90.0% | assay - | assay - | assay - |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum
Schofield.CR, et al.
Journal of Chromatography. B, Biomedical Applications, 1002, 169-175 (2015)
Preparation, characterization and physicochemical properties of DOPE-PEG2000 stabilized oleic acid-soy lecithin liposomes (POLL)
Suk ERV and Misran M
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 513, 267-273 (2017)
The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia
Kurtys E, et al.
Neurochemistry International, 99, 206-214 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F7878-100MG | 04061833619803 |
| F7878-500MG | 04061833619827 |
| F7878-1G | 04061833619810 |
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What temperature should I store folinic acid calcium salt hydrate (F7878)? Is this reagent UV sensitive? Thanks.
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