G0750

Sigma-Aldrich

D-(+)-Galactose

≥99%

Synonym(s):
Galactose
Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
Molecular Weight:
180.16
Beilstein/REAXYS Number:
1724619
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

biological source

bovine (Ruminant- Cow, Ox, Buffalo)

assay

≥99%

form

powder

application(s)

HPLC: suitable

impurities

≤0.1% glucose

mp

168-170 °C (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless

SMILES string

OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O

InChI

1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1

InChI key

GZCGUPFRVQAUEE-KCDKBNATSA-N

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Application

Galactose has been used:
  • as a component of galactosyltransferase labeling buffer.
  • as a supplement in MRS broth for the growth of thermophilic lactobacilli
  • to induce the expression of uncoupling protein (UCP) in yeast transformants

Packaging

10, 25, 50, 100, 500 g in poly bottle
10 mg in glass bottle
1 kg in poly bottle

Biochem/physiol Actions

Galactose is a simple monosaccharide that serves as an energy source and as an essential component of glycolipids and glycoproteins. Galactose contributes to energy metabolism via its conversion to glucose by the enzymes that constitute the Leloir pathway. Defects in the genes encoding these proteins lead to the metabolic disorder galactosemia.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
D L Murdza-Inglis et al.
The Journal of biological chemistry, 269(10), 7435-7438 (1994-03-11)
The uncoupling protein is one of a family of mitochondrial transport proteins involved in energy metabolism. It dissipates oxidative energy to generate heat, either by catalyzing proton transport directly or by catalyzing fatty acid anion transport, thus enabling fatty acids...
K W Turner et al.
Applied and environmental microbiology, 45(6), 1932-1934 (1983-06-01)
The ability to ferment galactose is a major characteristic which can be used to differentiate Lactobacillus helveticus (galactose positive) from Lactobacillus lactis and Lactobacillus bulgaricus (galactose negative). In milk cultures, galactose-positive strains produced d- and l-lactic acid with little galactose...
Susana M Cerritelli et al.
Nucleic acids research, 48(8), 4274-4297 (2020-03-19)
Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA. RNase H2-initiated ribonucleotide excision repair (RER) efficiently removes single...
Inge E Krabbendam et al.
Cell death & disease, 11(4), 263-263 (2020-04-25)
Metabolic flexibility is an essential characteristic of eukaryotic cells in order to adapt to physiological and environmental changes. Especially in mammalian cells, the metabolic switch from mitochondrial respiration to aerobic glycolysis provides flexibility to sustain cellular energy in pathophysiological conditions....
Luke E Formosa et al.
Cell reports, 31(3), 107541-107541 (2020-04-23)
Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The mitochondrial complex I intermediate assembly (MCIA) complex, containing assembly factors NDUFAF1, ECSIT, ACAD9...

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