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G4251

Sigma-Aldrich

L-Glutathione reduced

≥98.0%

Synonym(s):
γ-L-Glutamyl-L-cysteinyl-glycine, GSH
Linear Formula:
H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
CAS Number:
Molecular Weight:
307.32
Beilstein:
1729812
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

Assay

≥98.0%

form

powder

color

white

mp

192-195 °C (dec.) (lit.)

application(s)

detection

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI key

RWSXRVCMGQZWBV-WDSKDSINSA-N

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This Item
1.04090G6529G6013
L-Glutathione reduced ≥98.0%

Sigma-Aldrich

G4251

L-Glutathione reduced

Glutathione (reduced) suitable for biopharmaceutical production EMPROVE® bio Ph Eur

SAFC

1.04090

Glutathione (reduced)

L-Glutathione reduced BioXtra, ≥98.0%

Sigma-Aldrich

G6529

L-Glutathione reduced

L-Glutathione reduced suitable for cell culture, BioReagent, ≥98.0%, powder

Sigma-Aldrich

G6013

L-Glutathione reduced

assay

≥98.0%

assay

-

assay

≥98.0%

assay

≥98.0%

form

powder

form

-

form

powder

form

powder

color

white

color

-

color

white

color

white

mp

192-195 °C (dec.) (lit.)

mp

185-195 °C

mp

192-195 °C (dec.) (lit.)

mp

192-195 °C (dec.) (lit.)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

500

Quality Level

200

Quality Level

300

Amino Acid Sequence

γ-Glu-Cys-Gly

Application

L-Glutathione (GSH) reduced has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses.
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
Reduced L-glutathione (GSH) is a thiol compound and is associated with catabolism and transportation. Plasma GSH levels are associated with Parkinson′s diseases, Alzheimer′s, diabetes, macular degeneration, and HIV (human immunodeficiency virus) disease.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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