H1425000

Hydrocortisone hydrogen succinate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):
Cortisol 21-hemisuccinate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate, Hydrocortisone 21-hemisuccinate
Empirical Formula (Hill Notation):
C25H34O8
CAS Number:
Molecular Weight:
462.53
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

form

neat

CofA

certificate is enclosed in each package

mfr. no.

EDQM

Featured Industry

Pharmaceutical (small molecule)

format

neat

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC@12CCC(=O)C=C1CCC@H3C@@H4CCC@(O)(C(=O)COC(=O)CCC(O)=O)C@@4(C)CC@H(O)C@H23

InChI

1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1

InChI key

VWQWXZAWFPZJDA-CGVGKPPMSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the
issuing Pharmacopoeia.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Other Notes

Sales restrictions may apply.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin
Lucia Gagliardi et al.
The Journal of clinical endocrinology and metabolism, 99(11), 4149-4157 (2014-08-16)
Patients with Addison's disease (AD) report impaired subjective health status (SHS). Since cortisol exhibits a robust circadian cycle that entrains other biological clocks, impaired SHS may be due to the noncircadian cortisol profile achieved with conventional glucocorticoid replacement. Continuous subcutaneous...
Xiaolin Qi et al.
American journal of ophthalmology, 158(6), 1192-1198 (2014-08-20)
To investigate the morphologic changes and outcomes of the amniotic membrane as a carrier for allogeneic cultivated limbal epithelial transplantation. Prospective, noncomparative, interventional study. A total of 16 eyes receiving allogeneic cultivated limbal epithelial transplantation with amniotic membrane as a...
Takeshi Soma et al.
PloS one, 9(10), e110987-e110987 (2014-10-25)
We assessed the maintenance and distribution of epithelial stem/progenitor cells after corneal reconstruction using tissue-engineered oral mucosal cell sheets in a rat model. Oral mucosal biopsy specimens were excised from green fluorescent protein (GFP) rats and enzymatically treated with Dispase...
Maureen Keller-Wood et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(4), R405-R413 (2014-06-13)
In normal pregnancy, cortisol increases; however, further pathological increases in cortisol are associated with maternal and fetal morbidities. These experiments were designed to test the hypothesis that increased maternal cortisol would increase maternal glucose concentrations, suppress fetal growth, and impair...

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