I3021

Sigma-Aldrich

IGEPAL® CA-630

viscous liquid

Synonym(s):
Octylphenoxy poly(ethyleneoxy)ethanol, branched
Linear Formula:
(C2H4O)nC14H22O
CAS Number:
NACRES:
NA.21

Quality Level

description

non-ionic

form

viscous liquid

mol wt

~603

CMC

0.08 mM (20-25°C)

viscosity

250-350 cP, neat(25 °C)(lit.)

density

1.06 g/cm3 at 25 °C (lit.)

HLB

13

InChI

1S/C16H26O2/c1-15(2,3)12-16(4,5)13-6-8-14(9-7-13)18-11-10-17/h6-9,17H,10-12H2,1-5H3

InChI key

JYCQQPHGFMYQCF-UHFFFAOYSA-N

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General description

IGEPAL® CA-630 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40.

Application

IGEPAL® CA-630 has been used:
  • as a component of grinding buffer along with lithium dodecyl sulphate, tris-HCl, EDTA, NaCl, sodium deoxycholate, dithiothreitol and thiourea in RNA extraction process
  • along with Tris- HCl in incubation of Tachyzoites cultured in vero cells
  • as a component of nuclear extract buffer D+ containing HEPES, glycerol, KCl and EDTA for gel shift analysis
  • as a component of PI buffer along with NaH2PO4 to wash slides in FISH (fluorescence in situ hybridization) procedure
  • for solubilizing and isolation of membrane proteins

Packaging

50, 100, 500 mL in poly bottle

Other Notes

Nonionic, non-denaturing detergent

Quality

Chemically indistinguishable from Nonidet P-40, which is no longer commercially available.

Caution

May develop turbidity or sediment during storage. A clear liquid can be obtained on heating to 40°C.

Legal Information

IGEPAL is a registered trademark of Solvay

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 3

Flash Point(F)

483.8 °F

Flash Point(C)

251 °C

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Chromosome painting using repetitive DNA sequences as probes for somatic chromosome identification in maize.
Kato A, et al.
Proceedings of the National Academy of Sciences of the USA, 101(37), 13554-13559 (2004)
Detection of Potato mop top virus and Tobacco rattle virus using a multiplex real-time fluorescent reverse-transcription polymerase chain reaction assay.
Phytopathology, 90(5), 448-453 (2000)
Automated time-resolved immunofluorometric assay for Toxoplasma gondii-specific IgM and IgA antibodies: study of more than 130 000 filter-paper blood-spot samples from newborns.
Clinical Chemistry, 48(11), 1981-1986 (2002)
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene.
Molecular Immunology, 45(11), 3230-3237 (2008)
Giedrius Steponaitis et al.
Oncology letters, 12(5), 3305-3311 (2016-12-03)
Astrocytomas are one of the most common brain tumours; however, the current methods used to characterize these tumours are inadequate. The establishment of molecular markers may identify variables required to improve tumour characterization and subtyping, and may aid to specify...
Protocols
This page shows how to solubilize membrane proteins with products from Cytiva.
Read More

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