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MilliporeSigma

L5626

L-Lysine monohydrochloride

≥98% (HPLC), suitable for immunohistochemistry

Synonym(s):

(S)-2,6-Diaminohexanoic acid monohydrochloride

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About This Item

Linear Formula:
H2N(CH2)4CH(NH2)CO2H·HCl
CAS Number:
Molecular Weight:
182.65
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
211-519-9
MDL number:
Beilstein/REAXYS Number:
3563889

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Product Name

L-Lysine monohydrochloride, reagent grade, ≥98% (HPLC)

InChI key

BVHLGVCQOALMSV-JEDNCBNOSA-N

InChI

1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1

SMILES string

OC([C@@H](N)CCCCN)=O.[H]Cl

grade

reagent grade

assay

≥98% (HPLC)

form

powder

technique(s)

immunohistochemistry: suitable

color

white to off-white

mp

263 °C (dec.) (lit.)

application(s)

peptide synthesis

Quality Level

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1 of 4

This Item
18-1900PHR110167448
grade

reagent grade

grade

SAJ special grade

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

form

powder

form

powder

form

-

form

-

technique(s)

immunohistochemistry: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

assay

≥98% (HPLC)

assay

≥99.0%

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

300

color

white to off-white

color

-

color

-

color

white

Application

L-lysine monohydrochloride has been used:
  • as a component in pre-fixative solution for electron microscopy[1]
  • as a component in blocking solution for immunohistochemistry(IHC)[2]
  • in the preparation of Periodate-lysine-paraformaldehyde (PLP) fixative for IHC[3]

Biochem/physiol Actions

L-lysine is an essential amino acid in animals and humans. L-Lysine is necessary for protein synthesis in the body and proper growth. L-lysine lowers the cholesterol level by producing carnitine. L-lysine aids in calcium, zinc and iron absorption. Athletes take L-lysine as a supplement for lean mass building and for proper muscle and bone health. L-lysine competes with arginine during viral replication and reduces herpes simplex virus infection.[4] L-lysine supplementation reduces chronic anxiety in human.[5] Lysine reduces viscosity of serum albumin solution for injections.[6]

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection
Inoue N, et al.
Journal of Bioscience and Bioengineering, 117(5), 539-543 (2014)
Multispectral imaging of T and B cells in murine spleen and tumor
Feng Z, et al.
Journal of Immunology, 1502635-1502635 (2016)
Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia
Howden BP, et al.
Antimicrobial Agents and Chemotherapy, 50(9), 3039-3047 (2006)
Medicinal uses of L-Lysine: Past and future
Singh M, et al.
International Journal of Research in Pharmaceutical Sciences, 2(4), 637-642 (2016)
Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans
Smriga M, et al.
Biomedical Research, 28(2), 85-90 (2007)

Protocols

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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