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LIGHTOX14

Sigma-Aldrich

LightOx14

≥98% (HPLC)

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Empirical Formula (Hill Notation):
C23H25NO2
CAS Number:
Molecular Weight:
347.45

Assay

≥98% (HPLC)

form

powder

storage temp.

2-8°C

Related Categories

Application

Fluorescence microscopy, fluorescent retinoid binding assay, fluorescence spectroscopy.

Biochem/physiol Actions

Strong ligand for retinoic acid receptor proteins

Features and Benefits

LightOx14 is a synthetic analogue of all-trans-retinoic acid (ATRA) that exhibits solvatochromatic fluorescence emission when excited with UV or 405 nm light. The compound is a strong ligand for the retinoic acid receptor proteins (RARs) and related cellular retinoic acid binding proteins (CRABPI/II) and can, therefore, be used as a replacement for ATRA in cellular assays involving retinoid signaling processes. LightOx14 can be utilized to study retinoid behaviour using fluorescence microscopy, employed in a competitive fluorometric ligand-binding assay for direct determination of the strength of binding of non-fluorescent retinoids to a protein target, and as a fluorophore in fluorescence spectroscopy.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

Chemical Equivalency 1ea=1mg

Legal Information

LightOx is a trademark of LightOx Ltd.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Articles

Fluorescent Retinoid Probes

Fluorescent retinoic acid analogues for use in cellular imaging, protein-ligand binding assays, and flow cytometry to bypass traditional problems associated with fluorescent probes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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