M3157

Supelco

Minaprine dihydrochloride

analytical standard

Synonym(s):
N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
Empirical Formula (Hill Notation):
C17H22N4O · 2HCl
CAS Number:
Molecular Weight:
371.30
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

form

neat

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Forensics and Toxicology
Pharmaceutical (small molecule)

format

neat

SMILES string

Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3

InChI

1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

InChI key

GNUCGROXDZMCJI-UHFFFAOYSA-N

Gene Information

human ... ACHE(43), CHRM1(1128), DRD2(1813), HTR2B(3357), HTR2C(3358), MAOA(4128), SLC6A4(6532)
rat ... Ache(83817), Camk2a(25400), Prkca(24680)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

1 g in poly bottle

Biochem/physiol Actions

Antidepressant

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
J G Edwards et al.
British journal of clinical pharmacology, 42(4), 491-498 (1996-10-01)
1. A double-blind, multicentre study comparing the efficacy and safety of minaprine and amitriptyline in patients with major depression was carried out. Five hundred and thirty-one patients were randomly assigned to treatment with either minaprine 100 mg, 200 mg or...
S Cabib et al.
Psychopharmacology, 121(1), 73-80 (1995-09-01)
Different types of clinically effective antidepressants prevent the behavioral effects of experimental stress, and some of these treatments affect mesolimbic dopamine (DA) functioning. Animal studies have demonstrated that repeated psychostimulant administration and repeated or chronic stressful experiences also affect mesolimbic...
C A Lorenzini et al.
Pharmacology, biochemistry, and behavior, 45(2), 481-485 (1993-06-01)
The nootropic activity of 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl-pyridazine dihydrochloride (minaprine) has been investigated in intact male, adult Long Evans rats by means of an active avoidance paradigm. In the light-dark box apparatus, the rat had to learn the active avoidance response of going...
A Imperato et al.
Neuroscience letters, 166(1), 69-72 (1994-01-17)
Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced...
S Puglisi-Allegra et al.
Psychopharmacology, 113(3-4), 476-480 (1994-01-01)
Post-training administration of minaprine (2.5, 5 and 10 mg/kg) dose-dependently improved retention of an inhibitory avoidance response in mice. Animals receiving nine daily injections of 5 mg/kg and administered a challenge dose post-training showed an improvement in memory consolidation similar...

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