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M4125

Sigma-Aldrich

D-Mannitol

≥98% (GC)

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Synonym(s):
Mannite
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
1721898
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

plant

Quality Level

assay

≥98% (GC)

form

powder

color

white

useful pH range

5.0-6.5 (25 °C, 182 g/L, (77 °F ))

mp

167-170 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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1 of 4

This Item
M95461731178513
D-Mannitol ≥98% (GC)

M4125

D-Mannitol

-
D-Mannitol BioXtra, ≥98% (HPLC)

M9546

D-Mannitol

Premium Grade
D-Mannitol tested according to Ph. Eur.

17311

D-Mannitol

-
D-Mannitol ≥99.9999% (metals basis), for boron determination

78513

D-Mannitol

-
biological source

plant

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

water: 100 mg/mL, clear, colorless

solubility

H2O: 1 M, clear, colorless

solubility

water: soluble(lit.)

solubility

-

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

-

General description

D-Mannitol, a naturally occurring six-carbon sugar alcohol or polyol, is found in plants such as algae, onions, grasses, and olives. It is considered safe due to its relatively lower glycemic index than sucrose.

Application

D-Mannitol has been used:
  • in osmotic loading to adjust the osmolarity of solutions
  • as a component of test sugar solution for cellobiose-mannitol permeability test
  • as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
  • to treat the control cells and regulate the osmotic pressure of high glucose

D-mannitol has been used as a hydroxyl radical scavenger and as a medium supplement.

Biochem/physiol Actions

D-Mannitol may play an important role in lipolysis and fat oxidation as it can enhance the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC). It serves as an anti-obesity supplement. D-Mannitol stimulates the synthesis of short-chain fatty acids (SCFAs), which regulate lipid metabolism in the liver.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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S J Upton et al.
Journal of clinical microbiology, 33(2), 371-375 (1995-02-01)
Surface-sterilized oocysts of Cryptosporidium parvum were applied to subconfluent monolayers of human adenocarcinoma (HCT-8) cells grown on coverslips in six-well cluster plates. Parasite-infected cultures were then incubated in RPMI 1640 with 10% fetal bovine serum, 15 mM HEPES (N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid)
A Matsuzaki et al.
Cancer research, 49(20), 5702-5707 (1989-10-15)
Rat 3Y1 fibroblasts transformed by the E1A gene of adenovirus type 12 (E1A-3Y1 cells) are highly sensitive to the cell-killing effect of 1,3-dilinoleoylglycerol (DLG) administered in a culture medium, whereas the parental 3Y1 cells are less sensitive (H. Shimura et
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Marieke Dubois et al.
Plant physiology, 169(1), 166-179 (2015-05-23)
Leaf growth is a tightly regulated and complex process, which responds in a dynamic manner to changing environmental conditions, but the mechanisms that reduce growth under adverse conditions are rather poorly understood. We previously identified a growth inhibitory pathway regulating

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