If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
M4125
D-Mannitol
≥98% (GC)
Synonym(s):
Mannite
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
100 g | Available to ship TODAYfromMILWAUKEE | $36.90 |
500 g | Available to ship TODAYfromMILWAUKEE | $54.00 |
1 kg | Available to ship TODAYfromMILWAUKEE | $86.90 |
5 kg | Estimated to ship onJuly 09, 2026fromMILWAUKEE | $341.00 |
About This Item
$36.90
Available to ship TODAYDetails
biological source
plant
Quality Segment
assay
≥98% (GC)
form
powder
color
white
useful pH range
5.0-6.5 (25 °C, 182 g/L, (77 °F ))
mp
167-170 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI key
FBPFZTCFMRRESA-KVTDHHQDSA-N
General description
Application
- in osmotic loading to adjust the osmolarity of solutions
- as a component of test sugar solution for cellobiose-mannitol permeability test
- as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
- to treat the control cells and regulate the osmotic pressure of high glucose
Biochem/physiol Actions
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (GC) | assay ≥98% (HPLC) | assay ≥99.0% (sum of enantiomers, HPLC) | assay ≥97% |
| biological source plant | biological source - | biological source - | biological source - |
| solubility water: 100 mg/mL, clear, colorless | solubility H2O: 1 M, clear, colorless | solubility H2O: 0.1 g/mL, clear, colorless | solubility water: soluble(lit.) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| storage temp. room temp | storage temp. - | storage temp. - | storage temp. - |
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Storage Class
11 - Combustible Solids
ppe
Eyeshields, Gloves, type N95 (US)
flash_point_f
Not applicable
flash_point_c
Not applicable
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the particle size on this product? Looking for a larger particle size 100-250um
1 answer-
Unfortunately, the particle size is not determined for this product.
Helpful?
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IS IT TESTED ON ANIMAL CELL CULTURE
1 answer-
This product has not been tested with mammalian cell culture. It is cited to have been used in primary retinal cell culture.
Kindly review the following publication: Trotta MC, Pieretti G, Petrillo F, Alessio N, Hermenean A, Maisto R, D'Amico M. Resolvin D1 reduces mitochondrial damage to photoreceptors of primary retinal cells exposed to high glucose. J Cell Physiol. 2020 May;235(5):4256-4267. doi: 10.1002/jcp.29303. Epub 2019 Oct 14. PMID: 31612492.In addition, product M1902 has been tested for use in plant culture and product 63560 has been tested for use in microbiology. See the links below to review each product.
M1902
https://www.sigmaaldrich.com/product/sigma/m1902
63560
https://www.sigmaaldrich.com/product/sial/63560Helpful?
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Hi! Is this product safe to use in studies for animals?
1 answer-
This product is intended for research use only. Currently, no D-Mannitol product is offered that is tested for in vivo or in vitro use.
For use in animal models, product M8429 may be a more suitable option. While still a research-grade reagent, this product meets USP, EP, and FCC specifications.Please see the link below to review this product option:
https://www.sigmaaldrich.com/product/sial/m8429In either case, the end user would have to determine suitability.
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I have a question about mannitol (as an excipient in a medicinal product). The questions would be the following: Is mannitol absorbed at intestinal level? Do you know about a possible interaction between mannitol and disulfiram? Thank you.
1 answer-
Please note, unless otherwise stated, this product is intended for research purposes only and not for use as a drug to be administered to animals or humans.
The in vivo metabolism of this product has not been evaluated. However, certain publications show that mannitol is absorbed by the small intestine.
The link below may provide helpful information:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802677/Helpful?
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