M8277

Midodrine hydrochloride

analytical standard, for drug analysis

• Synonym(s): (±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol
• Empirical Formula (Hill Notation): C₁₂H₁₈N₂O₄ · HCl
• CAS Number: 3092-17-9
• Molecular Weight: 290.74
• NACRES: NA.24
• PubChem Substance ID: 329818055
• UNSPSC Code: 41116107
• MDL number: MFCD00079455

Properties

• InChI key: MGCQZNBCJBRZDT-UHFFFAOYSA-N
• SMILES string: Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN
• InChI: 1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule); veterinary
• format: neat
• Quality Level: 100
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples[1] and pharmaceutical formulations[2] using different chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

General description

Midodrine is a prodrug[2] and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine,[2] which causes an elevation of the systemic blood pressure with the reduction in heart rate.[1]

Safety Information

• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable