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Key Documents

N1636

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide hydrate

purified by column chromatography, ≥99%

Synonym(s):

β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide

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About This Item

Empirical Formula (Hill Notation):
C21H27N7O14P2 · xH2O
CAS Number:
Molecular Weight:
663.43 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
41106305
eCl@ss:
39200202
PubChem Substance ID:
NACRES:
NA.55
Pricing and availability is not currently available.

Quality Level

assay

≥99%

form

crystalline powder

color

white

storage temp.

−20°C

SMILES string

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

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1 of 4

This Item
N7381N6522N3014
assay

≥99%

assay

-

assay

≥98%

assay

≥96.5% (HPLC), ≥96.5% (spectrophotometric assay)

form

crystalline powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

white

color

white to off-white

color

white to off-white

color

white to off-white

General description

β-Nicotinamide adenine dinucleotide (NAD) is an electron carrier[1] and a cofactor. It is ubiquitously found in the living system. NAD+ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD+ complexes, the enzyme-cofactor interactions are highly conserved.[2]

Application

β-Nicotinamide adenine dinucleotide hydrate has been used:
  • to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)[3]
  • in the reaction buffer for pyruvate kinase (PK) activity assay[4]
  • as a component of master mix for a high throughput screening[5]

Biochem/physiol Actions

β-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth.[6] It significantly participates in enzyme-catalyzed oxido-reduction processes[2] and many genetic processes. It is also involved in microbial catabolism.[6]
Electron acceptor

Packaging

Packaged by solid weight.

Other Notes

Crystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperatures than amorphous NAD.
This is the common form of NAD.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Questions

  1. Hi, I wanted to confirm whether this is the oxidized form of NADH with purity >99%.

    1 answer
    1. This product is the common form of NAD. ?-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. Therefore, it is not NAD+ or NADH, it is simply NAD.

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