N4126

Sigma-Aldrich

Nicotinic acid

≥98%

Synonym(s):
Pellagra preventive factor, Niacin, Pyridine-3-carboxylic acid, Vitamin B3, 3-Picolinic acid
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
Beilstein/REAXYS Number:
109591
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.

Quality Level

biological source

synthetic (organic)

assay

≥98%

form

powder

color

white to off-white

mp

236-239 °C (lit.)

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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General description

Nicotinic acid is also known as vitamin B3 or Niacin. It is a water soluble vitamin. Niacin can be either synthesized within the body or can be obtained from dietary sources.

Application

Nicotinic acid has been used:
  • as a component of the MS vitamins stock solution
  • for the detection of siderophores in Escherichia coli bacterial culture
  • as a component of the holidic medium for adult Drosophila .

Packaging

5, 100, 500 g in poly bottle
1 kg in poly bottle

Biochem/physiol Actions

Niacin is involved in the production of nicotinamide adenine dinucleotide (NAD+), which is used in the adenine triphosphate (ATP) production in mitochondrial oxidative phosphorylation. It also decreases hepatic production of very-low density lipoproteins (VLDL), and apolipoprotein B (apo-B). Niacin deficiency leads to pellagra.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36

Safety Statement

26

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

379.4 °F - closed cup

Flash Point(C)

193 °C - closed cup

Certificate of Analysis
Certificate of Origin
A procedure allowing up to eight generations of wheat and nine generations of barley per annum
Zheng Z, et al.
Euphytica, 191(2), 311-316 (2013)
An investigation into the pathogenic properties of Escherichia coli strains BLR, BL21, DH5 alpha and EQ1
Chart H, et al.
Journal of Applied Microbiology, 89(6), 1048-1058 (2000)
Variation in availability of niacin in grain products
Wall JS and Carpenter KJ
Food Technology (1988)
Vitamin B3 and sirtuin function
Denu J M
Trends in Biochemical Sciences, 30(9), 479-483 (2005)
A holidic medium for Drosophila melanogaster
Piper M D W, et al.
Nature Methods, 11(1), 100-100 (2014)
Articles
Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.
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