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N5535

Sigma-Aldrich

Niacinamide

meets USP testing specifications

Synonym(s):
Nicotinamide, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
Molecular Weight:
122.12
Beilstein:
383619
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

Agency

USP/NF
meets USP testing specifications

Assay

98.5-101.5% dry basis

form

crystals

color

white

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

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This Item
N063672345BP460
Niacinamide meets USP testing specifications

Sigma-Aldrich

N5535

Niacinamide

Nicotinamide BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

N0636

Nicotinamide

Nicotinamide ≥98.5% (HPLC)

Sigma-Aldrich

72345

Nicotinamide

Nicotinamide British Pharmacopoeia (BP) Reference Standard

BP460

Nicotinamide

assay

98.5-101.5% dry basis

assay

≥98% (HPLC)

assay

≥98.5% (HPLC)

assay

-

form

crystals

form

powder

form

powder

form

solid

color

white

color

white

color

colorless to white

color

-

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

pharmaceutical (small molecule)

General description

Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.

Application

Niacinamide has been used:
  • as a component of islet maturation culture media
  • to induce differentiation of insulin secreting cells
  • to compare its preclinical effectiveness with that of progesterone

Biochem/physiol Actions

Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD+), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency is associated with pellagra.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

302.0 °F - closed cup

Flash Point(C)

150 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T1503
Product Number
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25G
Pack Size/Quantity

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Role of nicotinamide in DNA damage, mutagenesis, and DNA repair
Surjana D, et al.
Journal of Nucleic Acids, 2010 (2010)
Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function
Lau H, et al.
Xenotransplantation (2019)
A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat
Peterson TC, et al.
Journal of Neurotrauma, 29(18), 2823-2830 (2012)
Stimulatory Role of Glycated Fetal Bovine Serum Along with Iron on In Vitro Production of Insulin by Differentiated Mouse Embryonic Stem Cells
Nishigaki I, et al.
Journal of Health Science, 57(4), 356-361 (2011)
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality

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