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NIST1950

Metabolites in human plasma

NIST® SRM® 1950

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NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

packaging

pkg of 5 x 1 mL

manufacturer/tradename

NIST®

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mass spectrometry (MS): suitable

application(s)

clinical research

format

matrix material

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Metabolites in human plasma NIST® SRM® 1950

NIST1950

Metabolites in human plasma

Human Serum NIST® SRM® 909c

NIST909C

Human Serum

vibrant-m

NIST967A

Creatinine in frozen human serum

form

liquid

form

-

form

liquid

form

liquid

manufacturer/tradename

NIST®

manufacturer/tradename

NIST®

manufacturer/tradename

NIST®

manufacturer/tradename

NIST®

application(s)

clinical research

application(s)

clinical research

application(s)

clinical testing

application(s)

clinical testing

format

matrix material

format

matrix material

format

matrix material

format

matrix material

packaging

pkg of 5 x 1 mL

packaging

pkg of 5 x 10 mL

packaging

pkg of 3 x 2 mL

packaging

pkg of set(4) (2 ea conc)

General description

SRM 1950 is designed to represent “normal” human plasma.

It was developed in a collaboration between the National Institute of Standards and Technology (NIST) and the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Analyses for value assignment were performed by NIST and the Centers for Disease Control and Prevention (CDC) (Atlanta, GA). All certified and reference values, with the exception of vitamin D-binding protein, are based on the agreement between the results from NIST methods and from the CDC, where available. The reference value for vitamin D-binding protein is based on the agreement between the results from a NIST method and the University of Washington method.

SRM 1950 _SDS

SRM 1950_CERT

Application

This Standard Reference Material (SRM) is intended primarily for the validation of methods for determining metabolites such as fatty acids, electrolytes, vitamins, hormones, and amino acids in human plasma and similar materials. This SRM can also be used for comparison of measurement technologies used in metabolomic studies and for quality assurance when assigning values to in-house reference materials.

The standard has been used:

  • to determine the accuracy of vitamin D in human serum by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
  • to determine the unbound free fatty acid profile of human plasma
  • to determine the C24 bile acids in human serum and urine samples by liquid chromatography-mass spectrometry (LC-MS) method

Features and Benefits

  • A unit of SRM 1950 consists of five vials, each containing approximately 1.0 mL of plasma
  • The associated uncertainties are expressed at the 95 %level of confidence
  • Information on product description, disposal, and transportation is available in the accompanying MSDS
  • The enclosed NIST certificate contains details on the expiry date, warning to users, instructions for right storage and use, preparation, and analysis of the RM

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3


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Quantification of vitamin D and 25-hydroxyvitamin D in soft tissues by liquid chromatography-tandem mass spectrometry
Lipkie TE, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 932, 6-11 (2013)
Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids
Zhu P, et al.
Analytical and Bioanalytical Chemistry, 410(21), 5287-5300 (2018)
Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate
Huber AH and Kleinfeld AM
Journal of Lipid Research, 58(3), 578-585 (2017)

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