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NIST3949

Folate Vitamers in Frozen Human Serum

NIST®SRM®

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Synonym(s):
Serum xx

grade

certified reference material

packaging

pkg of 3.072 g

manufacturer/tradename

NIST®

technique(s)

mass spectrometry (MS): suitable

application(s)

clinical testing

format

matrix material

storage temp.

-65 to -96°C

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technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

format

matrix material

format

matrix material

format

matrix material

format

matrix material

grade

certified reference material

grade

certified reference material

grade

certified reference material

grade

certified reference material

storage temp.

-65 to -96°C

storage temp.

-65 to -96°C

storage temp.

-

storage temp.

−70°C

packaging

pkg of 3.072 g

packaging

pkg of 14.7456 g

packaging

pkg of 4 vials (2 ea conc)

packaging

pkg of 2 vials, 1 level ea

General description

A unit of the Folate Vitamers standard reference material (SRM) 3949 consists of one vial each of three materials: low (Level 1), medium (Level 3), and high (Level 2) folates. Each vial contains approximately 1.0 mL of frozen human serum.

SRM_3949_cert

SRM_3949_SDS

Application

Folate Vitamers standard reference material (SRM) is intended for use in validating methods for determining folate vitamers in human serum, and for qualifying the in-house control materials analyzed using those methods.

Preparation Note

  • SRM 3949 is provided as a set of three vials of frozen serum that should be allowed to thaw at room temperature for at least 30 min under subdued light.
  • The contents of a vial should then be gently mixed prior to the removal of a test portion for analysis.
  • Precautions should be taken to avoid exposure to strong ultraviolet (UV) light and direct sunlight.

Other Notes

  • SRM 3949 is intended for research use.
  • Details on expiration, storage, safety, usage, and source are provided in the NIST certificate
  • Information on biomaterials, disposal, and transport is available in the SDS

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Seok-Won Hyung et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1179, 122725-122725 (2021-07-27)
One predominant and bioactive folate vitamer circulating in the blood is 5-methyltetrahydrofolate (5-Me-THF). In this study, a method for the accurate determination of 5-Me-THF in human plasma samples of various volumes was established using isotope dilution ultra-high performance liquid chromatography-mass
Johanna E Camara et al.
Analytical and bioanalytical chemistry, 415(5), 809-821 (2022-12-13)
The US National Institute of Standards and Technology (NIST) developed a Standard Reference Material® (SRM®) 3949 Folate Vitamers in Frozen Human Serum to replace SRM 1955 Homocysteine and Folate in Human Serum. The presence of increased endogenous levels of folic

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