P2125

Supelco

D-Pantethine

analytical standard

Synonym(s):
Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form
Empirical Formula (Hill Notation):
C22H42N4O8S2
CAS Number:
Molecular Weight:
554.72
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic (organic)

Quality Level

grade

analytical standard

assay

≥90%

form

neat

application(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

Featured Industry

Forensics and Toxicology
Veterinary
Vitamins, Nutraceuticals, and Natural Products

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1

InChI key

DJWYOLJPSHDSAL-ROUUACIJSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

1, 5 g in poly bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P2125.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

G Friberg et al.
Current eye research, 15(12), 1182-1190 (1996-12-01)
Solutions of the bovine lens protein gamma B (or gamma II) crystallin at neutral pH in the absence of reducing agents, undergo a slow, partial conversion to a new protein species, gamma IIH. This species is an aggregate composed of...
D H Fisher et al.
Journal of pharmaceutical and biomedical analysis, 15(5), 653-662 (1997-02-01)
In several animal models, preliminary studies have indicated that pantethine may inhibit cataract formation. Therefore, preclinical trials need to be conducted to study the pharmacology of pantethine in the ocular lens and to establish its efficacy. Since pantethine, which is...
J I Clark et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(26), 15185-15189 (1996-12-24)
The effects of pantethine, glutathione, and selected chemical reagents on the anti-aggregation activity of alpha-crystallin was evaluated. Protein aggregation was monitored by light scattering of solutions of denatured beta L-crystallin or alcohol dehydrogenase (ADH). The ratios of beta L-crystallin/alpha-crystallin and...
John I Clark
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1617), 20120104-20120104 (2013-03-27)
Cataract, neurodegenerative disease, macular degeneration and pathologies of ageing are often characterized by the slow progressive destabilization of proteins and their self-assembly to amyloid-like fibrils and aggregates. During normal cell differentiation, protein self-assembly is well established as a dynamic mechanism...
H Nomura et al.
Clinical therapeutics, 18(3), 477-482 (1996-05-01)
We compared the efficacy of two antihyperlipidemic drugs and the efficacy of diet plus exercise therapy in the treatment of patients with moderate hypercholesterolemia. The study included 48 patients with moderate hypercholesterolemia (serum total cholesterol [TC], 250 to 320 mg/dL)....

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