P4722

Pyridoxine hydrochloride

meets USP testing specifications

• Synonym(s): Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B₆ hydrochloride
• Empirical Formula (Hill Notation): C₈H₁₁NO₃ · HCl
• CAS Number: 58-56-0
• Molecular Weight: 205.64
• Beilstein/REAXYS Number: 3632435
• EC Number: 200-386-2
• MDL number: MFCD00012807
• UNSPSC Code: 12352205
• eCl@ss: 34058008
• PubChem Substance ID: 24898493
• NACRES: NA.21

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• agency: USP/NF; meets USP testing specifications
• assay: 98.0-102.0% dry basis
• form: powder
• color: white
• mp: 214-215 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: Cl[H].Cc1ncc(CO)c(CO)c1O
• InChI: 1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
• InChI key: ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Description

General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate.[1] The food sources of vitamin B₆ include grains, nuts, fruits, vegetables and meat.[2]

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats.[3] It has also been used as a reference standard to quantify vitamin B₆ in feed and digesta samples using high-performance liquid chromatography(HPLC).[4]

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids.[2] It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels.[5] Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin.[5] Pyridoxine in excess or deficient may lead to neuropathy.[6]

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)