Skip to Content
MilliporeSigma

Skip To

PHR1009

Caffeine

Pharmaceutical Secondary Standard; Certified Reference Material

Caffeine

Synonym(s):

1,3,7-Trimethylxanthine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
1 g

Available to ship TODAYfromMILWAUKEE

$122.00

About This Item

Linear Formula:
CH3(CH3)C6H4N4O2
CAS Number:
Molecular Weight:
194.19
UNSPSC Code:
12352210
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
17705

$122.00


Available to ship TODAYDetails


Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C0100000, traceable to USP 1085003

API family

dimenhydrinate, caffeine, pentoxifylline

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

234-236.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.

Application

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
1085003BP76656396
Caffeine British Pharmacopoeia (BP) Reference Standard

BP766

Caffeine

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, TraceCERT®

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-


Still not finding the right product?

Explore all of our products under Caffeine


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. What is the minimum potency of Product name : Caffeine CAS 58-08-2 Product Number : PHR1009

    1 answer
    1. The purity of this product is tested to demonstrate traceability to British Pharmacopoeia, European Pharmacopoeia, and United States Pharmacopeia pharmaceutical standards. The potency is not determined.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

Active Filters

  1. 1 Ratings-Only Review