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PHR1013

Supelco

Salicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2-Hydroxybenzoic acid
Linear Formula:
2-(HO)C6H4CO2H
CAS Number:
Molecular Weight:
138.12
Beilstein:
774890
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 775
traceable to Ph. Eur. S020000
traceable to USP 1609002

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)

API family

salicylic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

211 °C (lit.)

mp

158-161 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)c1ccccc1O

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

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This Item
52341PHR1643PHR1746
Salicylic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1013

Salicylic acid

Salicylic acid certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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52341

Salicylic acid

4-Aminosalicylic acid Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1746

4-Aminosalicylic acid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

General description

Salicylic acid is an important material in pharmaceutical industry, obtained via the decomposition of acetylsalicylic acid. Salicylic acid is widely used in food industry for producing dyes and artificial scents. It also shows therapeutic potential in protecting the skin from sun damage and hence finds applications in cosmetics and medicine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Salicylic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrofluorometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3036 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

314.6 °F - closed cup

Flash Point(C)

157 °C - closed cup


Certificates of Analysis (COA)

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Nickel?aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples
Abdolmohammad-Zadeh H, et al.
Talanta, 84(2), 368-373 (2011)
Simultaneous determination of naproxen, salicylic acid and acetylsalicylic acid by spectrofluorimetry using partial least-squares (PLS) multivariate calibration
Navalon A, et al.
Talanta, 48(2), 469-475 (1999)
E Benfeldt et al.
Acta dermato-venereologica, 79(5), 338-342 (1999-09-24)
Our aim was to simultaneously investigate 2 techniques for in vivo sampling of peripheral compartment pharmacokinetics after systemic administration of acetylsalicylic acid. Ten volunteers were given 2 g acetylsalicylic acid orally. Blood samples and dialysates from 4 microdialysis probes inserted
Dorothea Ellinger et al.
Plant physiology, 161(3), 1433-1444 (2013-01-22)
A common response by plants to fungal attack is deposition of callose, a (1,3)-β-glucan polymer, in the form of cell wall thickenings called papillae, at site of wall penetration. While it has been generally believed that the papillae provide a
S Zaugg et al.
Journal of chromatography. B, Biomedical sciences and applications, 752(1), 17-31 (2001-03-20)
Acetylsalicylic acid (Aspirin) is rapidly metabolized to salicylic acid (salicylate) and other compounds, including gentisic acid and salicyluric acid. Monitoring of salicylate and its metabolites is of toxicological, pharmacological and biomedical interest. Three capillary electrophoresis (CE) methods featuring alkaline aqueous

Protocols

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