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PHR1032

Supelco

Hydrochlorothiazide

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
HCTZ, 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Empirical Formula (Hill Notation):
C7H8ClN3O4S2
CAS Number:
Molecular Weight:
297.74
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 186
traceable to Ph. Eur. H1200000
traceable to USP 1314009

API family

hydrochlorothiazide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI

1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

Inchi Key

JZUFKLXOESDKRF-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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This Item
BP186H47591314009
Hydrochlorothiazide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1032

Hydrochlorothiazide

Hydrochlorothiazide British Pharmacopoeia (BP) Reference Standard

BP186

Hydrochlorothiazide

Hydrochlorothiazide crystalline

Sigma-Aldrich

H4759

Hydrochlorothiazide

Hydrochlorothiazide United States Pharmacopeia (USP) Reference Standard

USP

1314009

Hydrochlorothiazide

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

300

Quality Level

-

Quality Level

200

Quality Level

-

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrochlorothiazide is an antihypertensive and a diuretic that is used for the control of hypertension.

Application

Hydrochlorothiazide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Carbonic anhydrase inhibitor
Carbonic anhydrase inhibitor

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5026 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Sigma-Aldrich

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Chlorothiazide

Simultaneous high-performance liquid chromatographic determination of telmisartan and hydrochlorothiazide in pharmaceutical preparation
Rane VP, et al.
Journal of Chromatographic Science, 46(10), 887-891 (2008)
Simultaneous determination of enalapril maleate and hydrochlorothiazide in tablets by derivative UV spectrophotometry and high-performance liquid chromatography
Carlucci G, et al.
International Journal of Pharmaceutics, 93(1-3), 245-248 (1993)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)
Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by second-order derivative spectrophotometry.
Panderi E I.
Journal of Pharmaceutical and Biomedical Analysis, 21(2), 257-265 (1999)
Johannes A N Dorresteijn et al.
Journal of hypertension, 31(2), 393-403 (2012-12-14)
The objective of this study is to determine the effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension. A randomized, four-way, double-blind, crossover study in 31 adults with previously untreated obesity-related

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