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Pharmaceutical Secondary Standard; Certified Reference Material

Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, Pyridine-3-carboxylic acid amide, Nicotinamide
Empirical Formula (Hill Notation):
CAS Number:
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EC Number:
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Quality Level


certified reference material
pharmaceutical secondary standard


traceable to BP 460
traceable to Ph. Eur. N0600000
traceable to USP 1462006


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


128-131 °C (lit.)


pharmaceutical (small molecule)



storage temp.


SMILES string




InChI key


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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Niacinamide may be used as a pharmaceutical reference standard for the determination of the analyte in plasma, pharmaceutical formulations and infant/Adult nutritional formula powder by various chromatography methods.

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
Niacinamide/Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC1697 in the slot below. This is an example certificate only and may not be the lot that you receive.


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Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids



Flash Point(F)

302.0 °F - closed cup

Flash Point(C)

150 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Simultaneous determination of water-soluble vitamins in SRM 1849 Infant/Adult Nutritional Formula powder by liquid chromatography--isotope dilution mass spectrometry
Goldschmidt RJ and Wolf WR
Analytical and Bioanalytical Chemistry, 397(2), 471-481 (2010)
Rapid determination of thiamine, riboflavin, niacinamide, pantothenic acid, pyridoxine, folic acid and ascorbic acid in Vitamins with Minerals Tablets by high-performance liquid chromatography with diode array detector
Jin P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 70(5), 151-157 (2012)
P Pfuhl et al.
Journal of pharmaceutical and biomedical analysis, 36(5), 1045-1052 (2004-12-29)
A sensitive, specific, accurate, and reproducible HPLC/MS-method for the simultaneous quantitative determination of niacin (NA) and its main metabolites niacinamide (NAM) and nicotinuric acid (NUR) in human plasma using chinolin-3-carboxylic acid as an internal standard was developed and validated according
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.


HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

Separation of Pyridoxine; Nicotinamide; Nicotinic acid; Folic acid; (−)-Riboflavin, meets USP testing specifications; L-Ascorbic acid

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