PHR1047

Supelco

Phenol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Hydroxybenzene
Linear Formula:
C6H5OH
CAS Number:
Molecular Weight:
94.11
Beilstein/REAXYS Number:
969616
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

3.24 (vs air)

vapor pressure

0.09 psi ( 55 °C)
0.36 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

1319 °F

expl. lim.

8.6 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

182 °C (lit.)

mp

40-42 °C (lit.)

density

1.071 g/mL at 25 °C (lit.)

Featured Industry

Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1524806

SMILES string

Oc1ccccc1

InChI

1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H

InChI key

ISWSIDIOOBJBQZ-UHFFFAOYSA-N

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General description

Phenol is a derivative of benzene and is majorly used in the manufacture of bisphenol A, phenolic resins and caprolactam. Its other applications include the manufacture of variety of compounds in pharma industry, dyes, explosives, rubber and agriculture.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phenol may be used as a standard in determining the concentration of phenol present in samples of water using gas chromatography coupled with electron capture detector (GC-ECD).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1665 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

hazcat

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B - STOT RE 2

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 2

Flash Point(F)

174.2 °F - closed cup

Flash Point(C)

79.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Encyclopaedia of Occupational Health and Safety: Industries and Occupations, 4 (1998)
Determination of trace amounts of phenol in river waters by gas chromatography
Rennie.JP
Analyst, 107, 327-330 (1982)
Masaharu Nakamura et al.
Bioorganic & medicinal chemistry, 21(7), 1643-1651 (2013-03-07)
We previously reported that bis-phenol derivatives, including LG190178 (3a), possess not only vitamin D receptor (VDR) agonistic activity, but also androgen receptor (AR) antagonistic activity. Here, we describe the design, synthesis and evaluation of silicon-containing bis-phenol derivatives, with the objective...
Britta T Eklund et al.
Marine pollution bulletin, 46(2), 171-181 (2003-02-15)
Toxic effects on macroalgae have been compiled. Eighty-two articles have been found in literature during 1959-2000. A total of 120 substances were investigated using 65 different macroalgae species. About one-third of the tested compounds were organic substances (33%), another third...
Rita A Busuttil et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(10), 2761-2772 (2014-03-25)
Gene-expression profiling has revolutionized the way we think about cancer and confers the ability to observe the synchronous expression of thousands of genes. The use of putative genome-level expression profiles has allowed biologists to observe the complex interactions of genes...
Articles
Separation of 2-Chlorophenol; 2,4-Dichlorophenol; 2,4,6-Tribromophenol; 2,4,6-Trichlorophenol; 2,4-Dinitrophenol; Pentafluorophenol; 2-Methylphenol, analytical standard; 2,3,4,6-Tetrachlorophenol; Pentachlorophenol; 4-Nitrophenol; 2-Bromophenol; 2,3,5,6-Tetrachlorophenol; 2,3,5-Trichlorophenol; 4-Chloro-3-methylphenol; 2,4,5-Trichlorophenol; 4-Methylphenol, analytical standard; 2,4-Dimethylphenol; 2-Nitrophenol; 3-Methylphenol, analytical standard; Phenol; 2-Methyl-4,6-dinitrophenol; 2,3,4-Trichlorophenol; 2,6-Dichlorophenol; 2,3,4,5-Tetrachlorophenol
Read More
Protocols
HPLC Analysis of Cresols and Phenol on Astec® CYCLOBOND® I 2000
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Separation of 2-Nitrophenol; Pentachlorophenol; 2-Bromophenol; Phenol; 4-Nitrophenol; 3-Methylphenol, analytical standard; 4-Chloro-3-methylphenol; 2,4-Dichlorophenol; 2,3,4,6-Tetrachlorophenol; 2-Methylphenol, analytical standard; 2,4,6-Trichlorophenol; 2,4-Dimethylphenol; 2-Chlorophenol
Read More
HPLC Analysis of Phenols on SUPELCOSIL™ LC-8
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