PHR1083

Supelco

Octocrylene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
OC, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate
Linear Formula:
(C6H5)2C=C(CN)CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
Molecular Weight:
361.48
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

form

neat

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.567 (lit.)

bp

218 °C/1.5 mmHg (lit.)

mp

−10 °C (lit.)

density

1.051 g/mL at 25 °C (lit.)

Featured Industry

Environmental
Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1477411

SMILES string

CCCCC(CC)COC(=O)\C(C#N)=C(/c1ccccc1)c2ccccc2

InChI

1S/C24H27NO2/c1-3-5-12-19(4-2)18-27-24(26)22(17-25)23(20-13-8-6-9-14-20)21-15-10-7-11-16-21/h6-11,13-16,19H,3-5,12,18H2,1-2H3

InChI key

FMJSMJQBSVNSBF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Octocrylene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0433 in the slot below. This is an example certificate only and may not be the lot that you receive.

Hazard Statements

hazcat

Aquatic Chronic 4

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 1

Flash Point(F)

453.2 °F - closed cup

Flash Point(C)

234 °C - closed cup

Certificate of Analysis

Certificate of Origin

The difficulties for a photolabile drug in topical formulations: The case of diclofenac
Ioele G, et al.
International Journal of Pharmaceutics, 465(1-2), 284-290 (2014)
Morgane Bachelot et al.
The Science of the total environment, 420, 273-279 (2012-02-15)
The accumulation of EHMC, OCT and OD-PABA, three common UV filter compounds, was investigated in marine mussels. Wild Mytilus edulis and Mytilus galloprovincialis were sampled in ten sites along the French Atlantic and Mediterranean coasts from June to November. In...
N Negreira et al.
Analytical and bioanalytical chemistry, 400(2), 603-611 (2011-02-22)
This work describes an effective, low solvent consumption and affordable sample preparation approach for the determination of eight UV filters in surface and wastewater samples. It involves sorptive extraction of target analytes in a disposable, technical grade silicone disc (5 mm...
D Kaiser et al.
Environmental pollution (Barking, Essex : 1987), 163, 84-90 (2012-02-14)
Chemical UV filters are used in sun protection and personal care products in order to protect consumers from skin cancer induced by ultraviolet (UV) radiation. The present study aims to evaluate the effects of three common UV filters butyl-methoxydibenzoylmethane (B-MDM)...
Martine Avenel-Audran et al.
Archives of dermatology, 146(7), 753-757 (2010-07-21)
Octocrylene is a new emerging photoallergen. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use and/or positive photopatch test reactions to this UV filter and draw attention to the unexpected association in adults with a history...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service