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PHR1153

Supelco

Triethyl citrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Ethyl citrate
Linear Formula:
HOC(COOC2H5)(CH2COOC2H5)2
CAS Number:
Molecular Weight:
276.28
Beilstein:
1801199
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

9.7 (vs air)

vapor pressure

1 mmHg ( 107 °C)

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.442 (lit.)

bp

235 °C/150 mmHg (lit.)

density

1.14 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1683606

storage temp.

2-30°C

SMILES string

CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC

InChI

1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

InChI key

DOOTYTYQINUNNV-UHFFFAOYSA-N

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General description

Triethyl citrate is an ester of citric acid and is commonly used as a plasticizer in pharmaceutical coatings including tablets, capsules, beads and granules for masking taste. It is also used as a flavoring agent in food.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Triethyl citrate can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

Values of analytes vary lot to lot.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8988 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

311.0 °F - closed cup

Flash Point(C)

155 °C - closed cup

Certificate of Analysis

Certificate of Origin

Oral Strip Technology: A review
Jaiswal, Hema
Indian Journal of Pharmaceutical and Biological Research, 2(2), 130-130 (2014)
Ethylcellulose--A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development
Wasilewska K and Winnicka K
Materials, 12(20), 3386-3386 (2019)
Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
Li Z, et al.
Journal of Chromatography A, 1104(1-2), 1-10 (2006)
Development and validation of a gradient HPLC method for the determination of clindamycin and related compounds in a novel tablet formulation.
Platzer DJ, White BA.
Journal of Pharmaceutical and Biomedical Analysis, 41(1), 84-88 (2006)
H M Fadda et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(3), 493-497 (2010-08-31)
Glass transition temperature (T(g)) measurements of polymers are conventionally conducted in the dry state with little attention to the environment they are designed to work in. Our aim was to develop the novel use of dynamic mechanical analysis (DMA) to

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