The purity of this product varies from lot to lot and is reported in the Certificate of Analysis. A review of recent lots indicates a purity range of 99.5% - 99.9%. Please see the link below to review a lot specific Certificate:
https://www.sigmaaldrich.com/product/sial/phr1191#product-documentation
PHR1191
Nitrofurantoin
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin, Furadoxyl, Nitrofurantoine
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About This Item
Empirical Formula (Hill Notation):
C8H6N4O5
CAS Number:
Molecular Weight:
238.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-646-5
Beilstein/REAXYS Number:
893207
MDL number:
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Quality Level
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1464001
API family
nitrofurantoin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
[O-][N+](=O)c1ccc(\C=N\N2CC(=O)NC2=O)o1
InChI
1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+
InChI key
NXFQHRVNIOXGAQ-YCRREMRBSA-N
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This Item | |||
|---|---|---|---|
| application(s) cleaning products | application(s) cleaning products | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| Quality Level 300 | Quality Level 200 | Quality Level - | Quality Level 300 |
| grade certified reference material, pharmaceutical secondary standard | grade analytical standard | grade pharmaceutical primary standard | grade certified reference material, pharmaceutical secondary standard |
| storage temp. 2-30°C | storage temp. - | storage temp. - | storage temp. 2-30°C |
| agency traceable to USP 1464001 | agency - | agency - | agency traceable to Ph. Eur. N0950000, traceable to USP 1465004 |
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nitrofurantoin, a synthetic, nitrofuran-derivative, is a widely used urinary antimicrobial compound that is effective against pulmonary fibrosis, neuropathy, hepatitis and hemolytic anemia.
Nitrofurantoin, a synthetic, nitrofuran-derivative, is a widely used urinary antimicrobial compound that is effective against pulmonary fibrosis, neuropathy, hepatitis and hemolytic anemia.
Application
Nitrofurantoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by voltammetry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
To see an example of a Certificate of Analysis for this material enter LRAA9007 in the slot below. This is an example certificate only and may not be the lot that you receive.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Detection of ampicillin contamination in nitrofurantoin preparations by high pressure liquid chromatography
Bracey A
Journal of Pharmaceutical Sciences, 62(10), 1695-1696 (1973)
Determination of nitrofurantoin drug in pharmaceutical formulation and biological fluids by square-wave cathodic adsorptive stripping voltammetry
Hammam E
Journal of Pharmaceutical and Biomedical Analysis, 30(3), 651-659 (2002)
Stripping voltammetric behaviour of toxic drug nitrofurantoin
Jain R, et al.
Journal of Hazardous Materials, 169(1-3), 667-672 (2009)
Liquid chromatographic and spectrophotometric determination of phenazopyridine hydrochloride, ampicilline trihydrate, and nitrofurantoine in pharmaceutical preparations
Palabiyik IM and Onur F
Analytical Letters, 37(10), 2125-2150 (2004)
Robin L P Jump et al.
Infection control and hospital epidemiology, 33(12), 1185-1192 (2012-11-13)
We introduced a long-term care facility (LTCF) infectious disease (ID) consultation service (LID service) that provides on-site consultations to residents of a Veterans Affairs (VA) LTCF. We determined the impact of the LID service on antimicrobial use and Clostridium difficile
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Welche Reinheit hat Nitrofurantoin PHR1191-16?
1 answer-
Helpful?
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How to dissolve product PHR1191, Nitrofurantoin?
1 answer-
The solubility of product number PHR1191, Nitrofurantoin, is as follows:
- Soluble in DMF: 50 mg/mL
According to the literature, Nitrofurantoin is:
- Soluble in organic solvents, which should be purged with an inert gas, such as:
- Ethanol (approx. 15 mg/mL)
- DMSO (approx. 25 mg/mL)
- DMF (approx. 25 mg/mL)
- Sparingly soluble in aqueous buffers.Helpful?
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