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Methyl Ethyl Ketone

Pharmaceutical Secondary Standard; Certified Reference Material

Ethyl methyl ketone, 2-Butanone, MEK, Methyl ethyl ketone
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


certified reference material
pharmaceutical secondary standard


traceable to USP 1430101

vapor density

2.49 (vs air)

vapor pressure

71 mmHg ( 20 °C)


current certificate can be downloaded

autoignition temp.

960 °F

expl. lim.

10.1 %


HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.379 (lit.)


80 °C (lit.)


−87 °C (lit.)


0.805 g/mL at 25 °C (lit.)


pharmaceutical (small molecule)



storage temp.


SMILES string




InChI key


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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 2-Butanone (Methyl ethyl ketone, MEK), an aliphatic ketone, is considered as an aprotic and protophilic solvent. Its ability as an anticonvulsive agent in lithium-pilocarpine-induced status epilepticus in rats is reported.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC0146 in the slot below. This is an example certificate only and may not be the lot that you receive.


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Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids



Flash Point(F)

26.6 °F - closed cup

Flash Point(C)

-3 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition (2012)
Yang Cao et al.
British journal of haematology, 168(5), 701-707 (2014-11-06)
CXCR4(WHIM) frameshift and nonsense mutations follow MYD88(L265P) as the most common somatic variants in Waldenström Macroglobulinaemia (WM), and impact clinical presentation and ibrutinib response. While the nonsense (CXCR4(S338X) ) mutation has been investigated, little is known about CXCR4 frameshift (CXCR4(FS)
L Schafranek et al.
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Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However
Alejandro Carazo Fernández et al.
Toxicology letters, 233(2), 68-77 (2015-01-28)
The constitutive androstane receptor (CAR) is a crucial transcriptional regulator of key xenobiotic-metabolizing enzymes such as cytochrome P450 CYP3A4, CYP2C9 and CYP2B6. The flavonoids chrysin, baicalein and galangin have been reported to activate CAR and interfere with EGFR signaling. Nevertheless
S I Labidi-Galy et al.
Oncogene, 34(3), 373-383 (2014-01-29)
High-grade serous ovarian carcinoma (HGSOC) and basal-like breast cancer (BLBC) share many features including TP53 mutations, genomic instability and poor prognosis. We recently reported that Elafin is overexpressed by HGSOC and is associated with poor overall survival. Here, we confirm


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US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

US EPA Method 8260 describes the analysis of volatile organic compounds in solid wastes and ground waters. This application illustrates the analysis of many compounds commonly analyzed by this method using purge and trap coupled to GC-MS.

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