PHR1210

Supelco

Cumene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2-Phenylpropane, (1-Methylethyl)benzene, Isopropylbenzene, NSC 8776
Linear Formula:
C6H5CH(CH3)2
CAS Number:
Molecular Weight:
120.19
Beilstein/REAXYS Number:
1236613
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

4.1 (vs air)

vapor pressure

8 mmHg ( 20 °C)
9.7 mmHg ( 37.7 °C)

form

neat

CofA

current certificate can be downloaded

autoignition temp.

797 °F

expl. lim.

6.5 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.491 (lit.)

bp

152-154 °C (lit.)

mp

−96 °C (lit.)

density

0.864 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1151709

SMILES string

CC(C)c1ccccc1

InChI

1S/C9H12/c1-8(2)9-6-4-3-5-7-9/h3-8H,1-2H3

InChI key

RWGFKTVRMDUZSP-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cumene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9023 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Statements

hazcat

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 3 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

87.8 °F - closed cup

Flash Point(C)

31.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Determination of Residual Solvents in Bulk Drug and Formulations
Singh P and Sinha M
American Journal of PharmTech Research, 3(4), 289-295 (2006)
A novel peroxy radical based oxidative stressing system for ranking the oxidizability of drug substances
Harmon PA. et al.
Journal of Pharmaceutical Sciences, 95(9), 2014-2028 (2006)
Mathieu Frenette et al.
Journal of the American Chemical Society, 128(51), 16432-16433 (2006-12-21)
A new class of thermally activated chain-breaking antioxidants is presented. Dimers of persistent carbon-centered radicals are able to inhibit the autoxidation of cumene and styrene with better rate constants than the commercial antioxidant Irganox HP-136 and 3,5-di-tert-butyl-4-hydroxyanisole. A dramatic increase...
A Getsoian et al.
International journal of pharmaceutics, 348(1-2), 3-9 (2007-10-20)
To emphasize the fact that solvents can be either critical or immaterial in crystallizing specific polymorphs, a method for obtaining multiple polymorphs of a compound using only one solvent is demonstrated. By varying the crystallization temperature and level of supersaturation...
Youji Okada et al.
Organic & biomolecular chemistry, 4(22), 4113-4117 (2007-02-23)
We have undertaken a detailed study of the antioxidant activity of allicin, one of the main thiosulfinates in garlic, in order to obtain quantitative information on it as a chain-breaking antioxidant. The antioxidant actions of allicin against the oxidation of...

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