PHR1219

Supelco

Acetone

Pharmaceutical Secondary Standard; Certified Reference Material

Linear Formula:
CH3COCH3
CAS Number:
Molecular Weight:
58.08
Beilstein/REAXYS Number:
635680
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

2 (vs air)

vapor pressure

184 mmHg ( 20 °C)

form

neat

CofA

current certificate can be downloaded

expl. lim.

13.2 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.359 (lit.)

bp

56 °C/760 mmHg (lit.)

mp

−94 °C (lit.)

density

0.791 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1006801

SMILES string

CC(C)=O

InChI

1S/C3H6O/c1-3(2)4/h1-2H3

InChI key

CSCPPACGZOOCGX-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Acetone is an organic compound and in contrast to petroleum based hexane, it is a biorenewable solvent obtained via fermentation. It is generally used as a solvent for many gums, resins, and in the production of plastics.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5525 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

hazcat

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supp Hazards

EUH066

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

1.4 °F - closed cup

Flash Point(C)

-17.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Sinisa Bjelic et al.
Journal of molecular biology, 426(1), 256-271 (2013-10-29)
Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the...
Oleksiy Krupin et al.
Optics express, 21(1), 698-709 (2013-02-08)
Straight long-range surface plasmon waveguides are demonstrated as biosensors for the detection of cells, proteins and changes in the bulk refractive index of solutions. The sensors consist of 5 μm wide 22 nm thick Au stripes embedded in polymer (CYTOP™)...
Juan A López-Ráez et al.
Plant science : an international journal of experimental plant biology, 230, 59-69 (2014-12-07)
Apocarotenoids are a class of compounds that play important roles in nature. In recent years, a prominent role for these compounds in arbuscular mycorrhizal (AM) symbiosis has been shown. They are derived from carotenoids by the action of the carotenoid...
Len Verbeke et al.
Hepatology (Baltimore, Md.), 59(6), 2286-2298 (2013-11-22)
The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We studied the effect of short-term treatment with obeticholic acid (INT-747), a potent selective FXR...
Wanqiang Sheng et al.
Cell research, 24(12), 1387-1402 (2014-11-22)
T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5...
Articles
Butyl methyl ether; Acetic acid; 2-Butanone; Ethyl acetate; Tetrahydrofuran; 1-Butanol; Isopropyl acetate; Heptane; Propyl acetate; 3-Methylbutanol; 4-Methyl-2-pentanone; Isobutyl acetate; Butyl acetate; Dimethyl sulfoxide; Anisole; Cumene
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Protocols
Separation of 4-Methyl-2-pentanone; Dimethyl disulfide; Hexanal; 3-Methylpentane; Acetone
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HPLC Analysis of Urea, Carbamate, Triazine, Aniline Pesticides on Discovery® C18
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Separation of Acetone; Acetic acid; Propionic acid; Ethyl butyrate; Ethanol; Isoamyl acetate; Isobutyric acid; 3-Methyl-2-butanol; Methyl acetate; 1-Propanol; Acetal, ≥98%, FG; 2-Methyl-1-pentanol; Butyl acetate; Ethyl propionate; 3-Pentanol; 2-Pentanol, 98%; Ethyl isobutyrate; Isobutyl acetate; Acetaldehyde; Furfural; Butyric acid; Methanol; Ethyl acetate
Read More

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