PHR1227

Fluorouracil

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 5-Fluoro-2,4(1H,3H)-pyrimidinedione, 2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluorouracil, 5-FU
• Empirical Formula (Hill Notation): C₄H₃FN₂O₂
• CAS Number: 51-21-8
• Molecular Weight: 130.08
• Beilstein: 127172
• EC Number: 200-085-6
• MDL number: MFCD00006018
• PubChem Substance ID: 329823233
• NACRES: NA.24

Properties

• Quality Level: 300
• grade: certified reference material; pharmaceutical secondary standard
• Agency: traceable to BP 995; traceable to Ph. Eur. F0250000; traceable to USP 12790000
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 282-286 °C (dec.) (lit.)
• application(s): cleaning products; cosmetics; food and beverages; personal care; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: FC1=CNC(=O)NC1=O
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI key: GHASVSINZRGABV-UHFFFAOYSA-N
• Gene Information: human ... TYMS(7298)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Fluorouracil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by different analytical techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3468 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 - H351
• Precautionary Statements: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3