PHR1229

Supelco

Ethylbenzene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Ethylbenzene, Phenylethane, NSC 406903
Linear Formula:
C6H5C2H5
CAS Number:
Molecular Weight:
106.17
Beilstein/REAXYS Number:
1901871
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

3.7 (vs air)

vapor pressure

10 mmHg ( 20 °C)
19 mmHg ( 37.7 °C)

CofA

current certificate can be downloaded

autoignition temp.

810 °F

expl. lim.

6.7 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.495 (lit.)

bp

136 °C (lit.)

mp

−95 °C (lit.)

density

0.867 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1265457

SMILES string

CCc1ccccc1

InChI

1S/C8H10/c1-2-8-6-4-3-5-7-8/h3-7H,2H2,1H3

InChI key

YNQLUTRBYVCPMQ-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ethylbenzene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3557 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Target Organs

hearing organs

RIDADR

UN1175 - class 3 - PG 2 - Ethylbenzene

WGK Germany

WGK 1

Flash Point(F)

71.6 °F - closed cup

Flash Point(C)

22.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

A validated GC?MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules.
Deconinck E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 70(1-2), 64-70 (2012)
Static headspace gas chromatographic method for quantitative determination of residual solvents in pharmaceutical drug substances according to European Pharmacopoeia requirements.
Otero R, et al.
Journal of Chromatography A, 1057(1-2), 193-201 (2004)
E Jindrová et al.
Folia microbiologica, 47(2), 83-93 (2002-06-13)
Several aerobic metabolic pathways for the degradation of benzene, toluene, ethylbenzene and xylene (BTEX), which are provided by two enzymic systems (dioxygenases and monooxygenases), have been identified. The monooxygenase attacks methyl or ethyl substituents of the aromatic ring, which are...
Abby A Li et al.
Neurotoxicology, 31(3), 247-258 (2010-02-23)
The potential for neurotoxicological and immunotoxicological effects of ethylbenzene was studied in young adult Crl:CD(SD) rats following 90-day oral (neurotoxicity) or 28-day inhalation (immunotoxicity) exposures. In the neurotoxicity study, ethylbenzene was administered orally via gavage twice daily at 0, 25...
Leigh Henderson et al.
Mutation research, 635(2-3), 81-89 (2007-05-08)
Ethylbenzene is an important industrial chemical that has recently been classified as a possible human carcinogen (IARC class 2B). It induces tumours in rats and mice, but neither the relevance of these tumours to humans nor their mechanism of induction...

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