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PHR1257

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Lidocaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Lidocaine hydrochloride monohydrate, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
Molecular Weight:
288.81
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 214
traceable to Ph. Eur. L0600000
traceable to USP 1366013

API family

lidocaine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

InChI key

YECIFGHRMFEPJK-UHFFFAOYSA-N

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This Item
L06000001366013BP214
vibrant-m

PHR1257

Lidocaine hydrochloride

vibrant-m

L0600000

Lidocaine hydrochloride

vibrant-m

1366013

Lidocaine hydrochloride

vibrant-m

BP214

Lidocaine hydrochloride

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics. It is used for regional nerve blocks and infiltrative administration of anaesthesia. It prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Sensitive determination of lidocaine hydrochloride and cetylpyridinium chloride in their binary mixtures in different pharmaceutical formulations by three spectrophotometric-based methods
  • Simultaneous analysis of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods
  • Quantification of ceftriaxone sodium and lidocaine HCl in human plasma samples by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS)
  • Quantitative analysis of lidocaine hydrochloride and miramistin in a wound healing gel sample by high-performance liquid chromatography (HPLC) combined with UV detection
  • Development of a method based on liquid–liquid extraction of nifedipine and lidocaine hydrochloride from human plasma samples for their subsequent analysis by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
  • Dispersive liquid-liquid microextraction (DLLME) followed by attenuated total reflectance-Fourier transform infrared measurement of dry films for the determination of lidocaine hydrochloride in human urine sample

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3669 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Lories I Bebawy et al.
Journal of chromatographic science, 54(4), 492-499 (2015-12-17)
Two sensitive and selective analytical methods were developed for simultaneous determination of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation. Method A was based on HPLC separation of the cited drugs with determination of the toxic lidocaine-related
Determination of lidocaine in urine at low ppm levels using dispersive microextraction and attenuated total reflectance-Fourier transform infrared measurements of dry films
Perez-Guaita D, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 121, 178-183 (2015)
Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel
Brkich LL, et al.
Pharmaceutical Chemistry Journal, 54, 69-72 (2020)
Fang-Chi Yang et al.
Neurobiology of learning and memory, 112, 186-194 (2013-07-31)
Learning active or reactive responses to fear involves different brain circuitry. This study examined how the nuclus accumbens (NAc), dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) may interact in memory processing for these two kinds of responses. Male Wistar
Shaun Mehta et al.
JAMA facial plastic surgery, 16(6), 414-418 (2014-09-12)
This study evaluates the postoperative outcomes achieved with incisionless otoplasty for the correction of prominauris. To determine whether incisionless otoplasty is a reliable and replicable technique in correcting prominauris. This study consisted of a retrospective electronic medical record review for

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