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PHR1270

Supelco

Fumaric Acid

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Fumaric acid
Linear Formula:
HOOCCH=CHCOOH
CAS Number:
Molecular Weight:
116.07
Beilstein/REAXYS Number:
605763
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. F0600000
traceable to USP 1286708

vapor pressure

1.7 mmHg ( 165 °C)

API family

fumaric acid

CofA

current certificate can be downloaded

autoignition temp.

1364 °F

expl. lim.

40 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

298-300 °C (subl.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)\C=C\C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

InChI key

VZCYOOQTPOCHFL-OWOJBTEDSA-N

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This Item
76635W248835F0600000
Fumaric Acid Pharmaceutical Secondary Standard; Certified Reference Material

PHR1270

Fumaric Acid

Fumaric acid certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

76635

Fumaric acid

Fumaric acid natural (US), ≥98%, FG

W248835

Fumaric acid

Fumaric acid European Pharmacopoeia (EP) Reference Standard

F0600000

Fumaric acid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

format

neat

format

neat

format

-

format

neat

Quality Level

300

Quality Level

300

Quality Level

400

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

FG, Halal, Kosher, natural (US)

grade

pharmaceutical primary standard

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Fumaric Acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1693 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

521.6 - 525.2 °F - open cup

flash_point_c

272 - 274 °C - open cup


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Fumaric acid

Spectrophotometric estimation of ketotifen fumarate in pharmaceutical formulations
Sastry CSP and Naidu PY
Microchimica Acta, 127(3-4), 219-223 (1997)
Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection
Verma KK, et al.
Analyst, 116(6), 641-645 (1991)
C Nieboer et al.
Journal of the American Academy of Dermatology, 20(4), 601-608 (1989-04-01)
For the past two decades fumaric acid (FA) therapy has become an increasingly popular treatment in Western Europe for psoriasis. FA therapy originally was developed by Schweckendiek and subsequently standardized by Schäfer. Schäfer's fumaric acid compound therapy (FACT) consists of
Carol A Roa Engel et al.
Applied microbiology and biotechnology, 78(3), 379-389 (2008-01-25)
The potential of fumaric acid as a raw material in the polymer industry and the increment of cost of petroleum-based fumaric acid raises interest in fermentation processes for production of this compound from renewable resources. Although the chemical process yields
Fumaric acid: a new feed additive for pigs.
Nutrition reviews, 43(8), 253-254 (1985-08-01)

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