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Sodium ascorbate

Pharmaceutical Secondary Standard; Certified Reference Material

L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt, (+)-Sodium L-ascorbate
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
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Quality Level


certified reference material
pharmaceutical secondary standard




current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


220 °C (dec.) (lit.)

Featured Industry

Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to PhEur Y0000039
traceable to USP 1613509

SMILES string




InChI key


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General description

Sodium ascorbate, also known as E301, is a sodium salt of ascorbic acid. It is generally used as an antioxidant in pharmaceutical formulations and food products.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards and pharmacopeia primary standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Sodium ascorbate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by titrimetry and liquid chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC1682 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids

WGK Germany


Certificate of Analysis

Certificate of Origin

Sodium Ascorbate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 35(6), 4018-4018 (2018)
Sodium Ascorbate
Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, 625-627 (2009)
Sodium Ascorbate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6997-6998 (2019)
Aleksander Hinek et al.
Journal of dermatological science, 75(3), 173-182 (2014-07-13)
Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis. Present studies explored whether and how the L-ascorbic acid derivative (+) sodium L-ascorbate (SA) would affect production of collagen and elastic...
Martin Sillesen et al.
The journal of trauma and acute care surgery, 76(1), 12-19 (2013-12-26)
Traumatic brain injury (TBI) and hemorrhagic shock (HS) can be associated with coagulopathy and inflammation, but the mechanisms are poorly understood. We hypothesized that a combination of TBI and HS would disturb coagulation, damage the endothelium, and activate inflammatory and...

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