PHR1310

Supelco

Benzene

Pharmaceutical Secondary Standard; Certified Reference Material

Empirical Formula (Hill Notation):
C6H6
CAS Number:
Molecular Weight:
78.11
Beilstein/REAXYS Number:
969212
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

2.77 (vs air)

vapor pressure

166 mmHg ( 37.7 °C)
74.6 mmHg ( 20 °C)

form

neat

CofA

current certificate can be downloaded

autoignition temp.

1043 °F

feature

nist traceable 3000

expl. lim.

8 %

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.501 (lit.)

bp

80 °C (lit.)

mp

5.5 °C (lit.)

density

0.874 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1601146

SMILES string

c1ccccc1

InChI

1S/C6H6/c1-2-4-6-5-3-1/h1-6H

InChI key

UHOVQNZJYSORNB-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Benzene may be used as a pharmaceutical reference standard for the determination of benzene residues in pharmaceutical products by various chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3166 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

hazcat

Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 1A - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 1B - Skin Irrit. 2 - STOT RE 1

Target Organs

Blood

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 3

Flash Point(F)

12.2 °F

Flash Point(C)

-11 °C

Certificate of Analysis

Certificate of Origin

A general static-headspace gas chromatographic method for determination of residual benzene in oral liquid pharmaceutical products.
Liu H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 54(2), 417-421 (2011)
Factors that influence the determination of residual solvents in pharmaceuticals by automated static headspace sampling coupled to capillary GC-MS.
Mulligan KJ and McCauley H
Journal of Chromatographic Science, 33(1), 49-54 (1995)
Matrix media selection for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Urakami K, et al.
Journal of Chromatography A, 1057(1-2), 203-210 (2004)
Paula Mayorga Burrezo et al.
Journal of the American Chemical Society, 137(11), 3834-3843 (2015-03-03)
We have used Raman spectroscopy to study the molecular and electronic structures of the radical cations and dications of carbon-bridged oligo(para-phenylenevinylene)s (COPVn, n = 1-6) possessing consecutive fused pentagons and hexagons, up to 19, along with COPV derivatives having electron-donating...
Deborah C Glass et al.
Occupational and environmental medicine, 71(4), 266-274 (2014-02-18)
Benzene exposure has been associated with increased risk of leukaemia and myelodysplastic syndrome. Existing studies are sparse for other lymphohaematopoietic cancer subtypes, such as myeloproliferative disease (MPD) and the related chronic myeloid leukaemia (CML). We pooled data from three petroleum...
Protocols
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HPLC Analysis of Benzene and Deuterated Benzene on Ascentis<sup>®</sup> Express C18
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GC Analysis of Xylene Isomers on SLB®-IL60 - The cresol (methylphenol) isomers are also precursors to many chemicals. This chromatogram of a mix of aromatic and methylphenol compounds was generated using an SLB-IL60 ionic liquid column. Its interaction mechanisms allow the separation of all three xylene isomers, and all three cresol isomers.
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Technical article page on -US EPA Method 8015 (modified): GC Analysis of Gasoline Range Organics (GRO) on Equity®-1 after Purge & Trap using "M" Trap
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