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PHR1323

Supelco

L-Cystine

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
L-Cystine, (R,R)-3,3′-Dithiobis(2-aminopropionicacid)
Linear Formula:
[-SCH2CH(NH2)CO2H]2
CAS Number:
Molecular Weight:
240.30
Beilstein:
1728094
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. C3300000
traceable to USP 1161586

API family

cystine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>240 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

InChI key

LEVWYRKDKASIDU-IMJSIDKUSA-N

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This Item
30200779539C8755
L-Cystine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1323

L-Cystine

L-Cystine ≥99.7% (TLC)

Sigma-Aldrich

30200

L-Cystine

L-Cystine produced by Wacker Chemie AG, Burghausen, Germany, ≥98.5%

Sigma-Aldrich

779539

L-Cystine

L-Cystine ≥98% (TLC), crystalline

Sigma-Aldrich

C8755

L-Cystine

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

peptide synthesis

application(s)

-

application(s)

cell analysis
peptide synthesis

format

neat

format

-

format

-

format

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

room temp

Quality Level

300

Quality Level

200

Quality Level

-

Quality Level

-

General description

L-Cysteine a sulfur-containing, proteingenic non-essential amino acid useful in numerous biological applications.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

L-Cysteine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3784 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Sigma-Aldrich

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L-Cystine

SAFC

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L-Cystine

L-Cystine-1,1′-13C2 99 atom % 13C, 98% (CP)

Sigma-Aldrich

676136

L-Cystine-1,1′-13C2

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Sigma-Aldrich

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l-Cysteine
Nonvitamin and Nonmineral Nutritional Supplements, 59(11), 53-58 (2019)
Simultaneous identification and determination of total content of aminoacids in food supplements-tablets by gas chromatography
Obreshkova DP, et al.
Asian journal of experimental biological sciences, 5, 57-68 (2012)
Determination of cysteine in pharmaceuticals via liquid chromatography with postcolumn derivatization
Jenke DR and Brown DS
Analytical Chemistry, 59(11), 1509-1512 (1987)
Quantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by liquid chromatography-UV detection-mass spectrometry.
Toussaint B,
Journal of Chromatography A, 896(1-2), 191-199 (2000)
Martijn J Wilmer et al.
American journal of physiology. Renal physiology, 299(5), F905-F916 (2010-09-10)
Renal proximal tubules are highly sensitive to ischemic and toxic insults and are affected in diverse genetic disorders, of which nephropathic cystinosis is the most common. The disease is caused by mutations in the CTNS gene, encoding the lysosomal cystine

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